RT Journal Article SR Electronic T1 A regional massive hemorrhage protocol developed through a modified Delphi technique JF CMAJ Open JO CMAJ FD Canadian Medical Association SP E546 OP E561 DO 10.9778/cmajo.20190042 VO 7 IS 3 A1 Jeannie L. Callum A1 Calvin H. Yeh A1 Andrew Petrosoniak A1 Mark J. McVey A1 Stephanie Cope A1 Troy Thompson A1 Victoria Chin A1 Keyvan Karkouti A1 Avery B. Nathens A1 Kimmo Murto A1 Suzanne Beno A1 Jacob Pendergrast A1 Andrew McDonald A1 Russell MacDonald A1 Neill K.J. Adhikari A1 Asim Alam A1 Donald Arnold A1 Lee Barratt A1 Andrew Beckett A1 Sue Brenneman A1 Hina Razzaq Chaudhry A1 Allison Collins A1 Margaret Harvey A1 Jacinthe Lampron A1 Clarita Margarido A1 Amanda McFarlan A1 Barto Nascimento A1 Wendy Owens A1 Menaka Pai A1 Sandro Rizoli A1 Theodora Ruijs A1 Robert Skeate A1 Teresa Skelton A1 Michelle Sholzberg A1 Kelly Syer A1 Jami-Lynn Viveiros A1 Josee Theriault A1 Alan Tinmouth A1 Rardi Van Heest A1 Susan White A1 Michelle Zeller A1 Katerina Pavenski YR 2019 UL http://www.cmajopen.ca/content/7/3/E546.abstract AB Background: A massive hemorrhage protocol (MHP) enables rapid delivery of blood components in a patient who is exsanguinating pending definitive hemorrhage control, but there is variability in MHP implementation rates, content and compliance owing to challenges presented by infrequent activation, variable team performance and patient acuity. The goal of this project was to identify the key evidence-based principles and quality indicators required to develop a standardized regional MHP.Methods: A modified Delphi consensus technique was performed in the spring and summer of 2018. Panellists used survey links to independently review and rate (on a 7-point Likert scale) 43 statements and 8 quality indicators drafted by a steering committee composed of transfusion medicine specialists and technologists, and trauma physicians. External stakeholder input from all hospitals in Ontario was sought.Results: Three rounds were held with 36 experts from diverse clinical backgrounds. Consensus was reached for 42 statements and 8 quality indicators. Additional modifications from external stakeholders were incorporated to form the foundation for the proposed MHP.Interpretation: This MHP template will provide the basis for the design of an MHP toolkit, including specific recommendations for pediatric and obstetrical patients, and for hospitals with limited availability of blood components or means to achieve definitive hemorrhage control. We believe that harmonization of MHPs in our region will simplify training, increase uptake of evidence-based interventions, enhance communication, improve patient comfort and safety, and, ultimately, improve patient outcomes.