| Study | High-sensitivity troponin T assay* | Conventional troponin assay | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Assay | Sensitivity | Specificity | NPV, % | PPV, % | Cut-off point and assay | Sensitivity | Specificity | NPV, % | PPV, % | |
| Reichlin et al. 2009 (9) | Elecsys 2010 (Roche Diagnostics) | 0.95 | 0.80 | 99 | 50 | Troponin T, 0.035 ng/mL (4th generation, Roche) | 0.72 | 0.97 | 94 | 85 |
| Christ et al. 2010 (10) | Elecsys 2010 (Roche Diagnostics) | 0.95 | 0.62 | 98.6 | 29.7 | Troponin T, 0.04 ng/mL (4th generation, Roche Diagnostics) | 0.65 | 0.91 | 93.8 | 54.2 |
| Aldous et al. 2011 (11) | Elecsys (Roche Diagnostics) | 0.84 | 0.84 | 91.2 | 71.9 | Troponin T, 0.03 ng/mL (Elecsys 2010, Roche Diagnostics) | 0.43 | 0.97 | 77.4 | 88.7 |
| Body et al. 2011 (12) | Roche | 0.85 | 0.82 | 96.1 | 52.4 | Troponin T, 0.01 ng/mL (4th generation) | 0.75 | 0.95 | 94.4 | 75.8 |
| Freund et al. 2011 (13) | Elecsys 2010 (Roche Diagnostics) | 0.93 | 0.82 | 99 | 47 | Troponin I, 0.06 ng/mL (Access analyzer, Beckman Coulter) or Troponin I, 0.14 ng/mL (Xpand HM analyzer, Siemens Healthcare Diagnostics) | 0.71 | 0.97 | 95 | 78 |
| Melki et al. 2011 (14) | Roche Diagnostics | 0.97 | 0.74 | 97 | 78 | Troponin T, 0.04 ng/mL (4th generation, Roche Diagnostics) | 0.79 | 0.94 | 82 | 93 |
| Reiter et al. 2011 (15) | Elecsys 2010 (Roche Diagnostics) | 0.98 | 0.49 | 99 | 38 | Troponin T, 0.035 ng/mL (Roche) | 0.76 | 0.96 | 93 | 86 |
| Weber et al. 2011 (16) | Elecsys (Roche Diagnostics) | 0.96 | 0.61 | 80 | 91 | Troponin T, 0.03 ng/mL (Elecsys, Roche Diagnostics) | 0.82 | 0.90 | 54 | 97 |
| Aldous et al. 2012 (17) | Elecsys (Roche Diagnostics) | 0.88 | 0.82 | 96.2 | 57.5 | Troponin I, 0.028 ng/mL (Architect system, Abbott Diagnostics) | NA | NA | NA | NA |
Note: NA = not available, NPV = negative predictive value, PPV = positive predictive value. *Cut-off point 14 ng/L.