Table 2: Assessment of the studies that tested the high-sensitivity troponin T assay or high-sensitivity troponin I assay for risk of bias using the Quality Assessment of Diagnostic Accuracy Studies tool⁸

Study	Representative spectrum?	Acceptable reference standard?	Acceptable delay between tests?	Partial verification avoided?	Differential verification avoided?	Incorporation avoided?	Reference standard results blinded?	Index test results blinded?	Uninterpretable results reported?	Withdrawals explained?	Sponsoring precluded?
Troponin T
Reichlin et al. 2009⁹	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes
Christ et al. 2010¹⁰	Yes	Yes	Yes	Yes	Yes	Yes	Unclear	Unclear	Yes	Yes	Yes
Aldous et al. 2011¹¹	No	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	Yes
Body et al. 2011¹²	Yes	Yes	Yes	Yes	Yes	Yes	Unclear	Yes	Yes	Yes	No
Freund et al. 2011¹³	Yes	Yes	Yes	Yes	Yes	Yes	Unclear	Yes	Yes	Yes	Unclear
Melki et al. 2011¹⁴	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Unclear
Reiter et al. 2011¹⁵	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes
Weber et al. 2011¹⁶	Yes	Yes	Yes	Yes	Yes	Yes	Unclear	Yes	Yes	Unclear	Unclear
Aldous et al. 2012¹⁷	Yes	Yes	Yes	Yes	Yes	Yes	Unclear	Yes	Yes	Yes	Unclear
Troponin I
Reichlin et al. 2009⁹	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes
Keller et al. 2009²⁴	Yes	Yes	Yes	Yes	Yes	Yes	Unclear	Yes	Yes	Yes	Unclear
Bhardwaj et al. 2011²³	Yes	Yes	Unclear	Yes	Yes	Yes	Unclear	Yes	Yes	Yes	Yes

Note: Yes = high quality, No = low quality. Weighted κ = 0.70, 95% confidence interval 0.54–0.87, p < 0.001 (indicates substantial agreement according to Koch and Landis).^18,19