| Characteristic | No. (%) of patients* | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Before weighting | After weighting† | |||||||||
| Sitagliptin n = 57 689 | Alternative hypoglycemic agent n = 83 405 | Standardized difference, %‡ | Sitagliptin n = 57 689 | Alternative hypoglycemic agent n = 55 705 | Standardized difference, %‡ | |||||
| Age at index date, yr | ||||||||||
| Mean | 73.98 | 75.07 | 17 | 73.98 | 74.07 | 2 | ||||
| Median | 73 | 74 | 73 | 73 | ||||||
| Standard deviation | 6.25 | 6.93 | 6.25 | 5.20 | ||||||
| 66–70 | 21 105 | (36.58) | 26 880 | (32.23) | 9 | 21 105 | (36.58) | 20 171 | (36.21) | 1 |
| 71–75 | 15 829 | (27.44) | 21 282 | (25.52) | 4 | 15 829 | (27.44) | 15 199 | (27.28) | 0 |
| 76–80 | 11 228 | (19.46) | 16 397 | (19.66) | 0 | 11 228 | (19.46) | 10 661 | (19.14) | 1 |
| 81–85 | 6 431 | (11.15) | 11 112 | (13.32) | 7 | 6 431 | (11.15) | 6 350 | (11.40) | 1 |
| 86–90 | 2 461 | (4.27) | 5 828 | (6.99) | 12 | 2 461 | (4.27) | 2 678 | (4.81) | 3 |
| > 90 | 635 | (1.10) | 1 906 | (2.29) | 9 | 635 | (1.10) | 646 | (1.16) | 1 |
| Female sex | 27 584 | (47.82) | 40 312 | (48.33) | 1 | 27 584 | (47.82) | 26 279 | (47.18) | 1 |
| Rural location | 5 997 | (10.40) | 12 396 | (14.86) | 13 | 5 997 | (10.40) | 6 275 | (11.26) | 3 |
| Long-term care facility | 1 446 | (2.51) | 5 581 | (6.69) | 20 | 1 446 | (2.51) | 1 594 | (2.86) | 2 |
| Income quintile§ | ||||||||||
| 1 | 12 582 | (21.81) | 18 233 | (21.86) | 0 | 12 582 | (21.81) | 12 447 | (22.34) | 1 |
| 2 | 13 048 | (22.62) | 18 029 | (21.62) | 2 | 13 048 | (22.62) | 12 134 | (21.78) | 2 |
| 3 | 11 601 | (20.11) | 16 572 | (19.87) | 1 | 11 601 | (20.11) | 11 150 | (20.02) | 0 |
| 4 | 10 860 | (18.83) | 16 320 | (19.57) | 2 | 10 860 | (18.83) | 10 845 | (19.47) | 2 |
| 5 | 9 419 | (16.33) | 13 878 | (16.64) | 1 | 9 419 | (16.33) | 8 894 | (15.97) | 1 |
| Missing | 179 | (0.31) | 373 | (0.45) | 2 | 179 | (0.31) | 234 | (0.42) | 2 |
| Prescribing physician | ||||||||||
| Endocrinology | 4 813 | (8.34) | 3 042 | (3.65) | 20 | 4 813 | (8.34) | 5 047 | (9.06) | 3 |
| General practice | 42 925 | (74.41) | 66 305 | (79.50) | 12 | 42 925 | (74.41) | 40 948 | (73.51) | 2 |
| Internal medicine | 2 454 | (4.25) | 2 281 | (2.73) | 8 | 2 454 | (4.25) | 2 407 | (4.32) | 0 |
| Nephrology | 342 | (0.59) | 778 | (0.93) | 4 | 342 | (0.59) | 360 | (0.65) | 1 |
| Other | 1 830 | (3.17) | 2 252 | (2.70) | 3 | 1 830 | (3.17) | 1 727 | (3.10) | 0 |
| Missing | 5 325 | (9.23) | 8 169 | (9.79) | 2 | 5 325 | (9.23) | 5 216 | (9.36) | 0 |
*Unless stated otherwise. †All patients identified before weighting were included in the analyses. The number of patients indicated represents a weighted total. ‡Standardized differences are less sensitive to sample size than traditional hypothesis tests. They provide a measure of the difference between groups divided by the pooled standard deviation; a value greater than 10% is interpreted as a meaningful difference between the groups. §Income was categorized into fifths of average neighbourhood income on the index date.