| Outcome | Men, no. (%) (n = 4454) | Women,no. (%) (n = 2461) | Unadjusted HR (95% CI) | Adjusted HR* (95% CI) | Adjusted event rate per 1000 person-years | |
|---|---|---|---|---|---|---|
| Men | Women | |||||
| Primary outcome† | 2860 (64.2) | 1644 (66.8) | 1.06 (1.00-1.13) | 0.99 (0.92-1.05) | 162.6 | 159.4 |
| Secondary outcome | ||||||
| Acute myocardial infarction | 618 (13.9) | 360 (14.6) | 1.07 (0.94-1.22) | 1.15 (1.00-1.31) | 30.1 | 34.5 |
| Stroke | 229 (5.1) | 140 (5.7) | 1.13 (0.92-1.40) | 1.02 (0.82-1.27) | 9.6 | 9.7 |
| Death | 2562 (57.5) | 1468 (59.6) | 1.06 (0.99-1.13) | 0.96 (0.90-1.03) | 130.0 | 124.1 |
| Major amputation | 764 (17.2) | 375 (15.2) | 0.89 (0.79-1.01) | 0.95 (0.84-1.08) | 38.3 | 36.2 |
| Minor amputation | 583 (13.1) | 211 (8.6) | 0.65 (0.55-0.76) | 0.73 (0.62-0.85) | 23.8 | 16.9 |
| Arterial bypass surgery | 685 (15.4) | 311 (12.6) | 0.82 (0.72-0.94) | 0.82 (0.71-0.94) | 39.2 | 31.5 |
| PCTA | 609 (13.7) | 330 (13.4) | 0.99 (0.87-1.14) | 1.04 (0.90-1.19) | 33.0 | 34.1 |
| Tertiary outcome | ||||||
| Congestive heart failure | 1144 (25.7) | 623 (25.3) | 1.01 (0.92-1.11) | 1.01 (0.91-1.12) | 60.9 | 61.4 |
| Carotid endarterectomy | 82 (1.8) | 34 (1.4) | 0.76 (0.51-1.14) | 0.77 (0.50-1.12) | 0.4 | 0.3 |
| Abdominal aortic aneurysm repair | 271 (6.1) | 126 (5.1) | 0.85 (0.69-1.05) | 0.92 (0.74-1.15) | 9.1 | 8.3 |
| Coronary revascularization | 442 (9.9) | 187 (7.6) | 0.77 (0.65-0.91) | 0.85 (0.71-1.02) | 18.2 | 15.5 |
| Initiation of dialysis | 749 (16.8) | 322 (13.1) | 0.77 (0.68-0.88) | 0.89 (0.78-1.03) | 21.4 | 18.2 |
Note: CI = confidence interval, HR = hazard ratio, PCTA = percutaneous transluminal angioplasty.
*Adjusted for patient age, income level, medical comorbidities and overall comorbidity burden, medication use, use of health care services (including hospital admissions, emergency department visits and outpatient physician visits) and ambulatory care group classification.
†A composite of death or hospital admission for acute myocardial infarction or stroke.