| Characteristic | Group, no. (%)* | Unadjusted OR (95% CI) | Adjusted OR†(95% CI) | ||
|---|---|---|---|---|---|
| Did not fill a domperidone prescription, n = 274 833 | Filled ≥ 1 domperidone prescription, n = 45 518 | ||||
| Age, yr | |||||
| < 25 | 36 196 (13.2) | 4707 (10.3) | Ref | Ref | |
| 25-29 | 72 928 (26.5) | 10 552 (23.2) | 1.11 (1.07-1.16) | 1.22 (1.16-1.27) | |
| 30-34 | 94 811 (34.5) | 15 990 (35.1) | 1.30 (1.25-1.34) | 1.51 (1.44-1.58) | |
| 35-39 | 57 116 (20.8) | 11 000 (24.2) | 1.48 (1.42-1.54) | 1.79 (1.70-1.87) | |
| ≥ 40 | 13 782 (5.0) | 3269 (7.2) | 1.82 (1.73-1.92) | 2.22 (2.08-2.36) | |
| Body mass index | |||||
| < 18.5 (underweight) | 10 869 (4.0) | 1492 (3.3) | 0.91 (0.86-0.97) | 0.95 (0.89-1.01) | |
| 18.5-24.9 (normal) | 126 799 (46.1) | 19 032 (41.8) | Ref | Ref | |
| 25.0-29.9 (overweight) | 42 309 (15.4) | 7810 (17.2) | 1.23 (1.19-1.27) | 1.25 (1.21-1.29) | |
| ≥ 30 (obese) | 22 724 (8.3) | 5739 (12.6) | 1.68 (1.62-1.74) | 1.72 (1.66-1.78) | |
| Unknown | 72 132 (26.2) | 11 445 (25.1) | |||
| Smoker | |||||
| No | 250 149 (91.0) | 41 513 (91.2) | Ref | Ref | |
| Yes | 24 684 (9.0) | 4005 (8.8) | 0.98 (0.94-1.01) | 1.06 (1.01-1.11) | |
| Income quintile | |||||
| Lowest | 56 255 (20.5) | 8225 (18.1) | 0.82 (0.79-0.84) | 0.90 (0.87-0.94) | |
| 2nd | 54 813 (19.9) | 9119 (20.0) | 0.93 (0.90-0.96) | 1.01 (0.97-1.05) | |
| 3rd | 54 909 (20.0) | 8942 (19.6) | 0.91 (0.88-0 94) | 0.97 (0.93-1.01) | |
| 4th | 54 543 (19.8) | 9488 (20.8) | 0.97 (0.94-1.00) | 1.02 (0.99-1.06) | |
| Highest | 54 107 (19.7) | 9706 (21.3) | Ref | Ref | |
| Chronic disease | |||||
| No | 167 129 (60.8) | 24 555 (53.9) | Ref | Ref | |
| Yes | 107 704 (39.2) | 20 963 (46.1) | 1.32 (1.30-1.35) | 1.26 (1.23-1.29) | |
| Parity | |||||
| 0 | 116 294 (42.3) | 26 328 (57.8) | Ref | Ref | |
| ≥ 1 | 158 539 (57.7) | 19 190 (42.2) | 0.53 (0.52-0.55) | 0.48 (0.47-0.49) | |
| Pregnancy type | |||||
| Singleton | 271 298 (98.7) | 43 863 (96.4) | Ref | Ref | |
| Mutiples | 3535 (1.3) | 1655 (3.6) | 2.90 (2.73-3.07) | 1.72 (1.59-1.86) | |
| Gestation, wk | |||||
| < 36 (preterm) | 19 887 (7.2) | 6502 (14.3) | 2.14 (2.08-2.21) | 1.83 (1.76-1.90) | |
| ≥ 37 (term) | 254 616 (92.6) | 38 963 (85.6) | Ref | Ref | |
| Mean ± SD | 38.8 ± 1.9 | 38.3 ± 2.5 | |||
| Delivery mode | |||||
| Vaginal | 194 204 (70.7) | 28 231 (62.0) | Ref | Ref | |
| Cesarian | 80 629 (29.3) | 17 287 (38.0) | 1.48 (1.44-1.50) | 1.20 (1.17-1.24) | |
Note: BMI = body mass index, CI = confidence interval, OR = odds ratio.
*Unless stated otherwise.
†Adjusted for age, BMI, smoking status, income, chronic disease, parity, pregnancy type, gestational age and delivery mode.