Case no. | Maternal | Infant | |||||||
---|---|---|---|---|---|---|---|---|---|
Timing of HIV diagnosis | Duration of antenatal combination antiretroviral therapy, wk | Adherence | Viral load, copies/mL | Gestational age, wk* | Birth weight, kg | Sex | Age at first positive HIV PCR result, d | Antiretroviral prophylaxis† | |
1 | Preconception | ≥ 4 | Suboptimal | ≥ 1000 | 37 | 3.28 | Female | 1 | ZDV/3TC/NVP |
2 | Preconception | < 4 | Suboptimal | Unknown | 36 | 1.64 | Male | 1 | ZDV/3TC/NVP |
3 | Preconception | < 4 | Suboptimal | Unknown | 36 | 2.27 | Female | 1 | ZDV/3TC/NVP |
4 | Preconception | < 4 | Suboptimal | < 50 | 38 | 2.65 | Female | 1309 | ZDV/3TC |
5 | Second trimester | ≥ 4 | Suboptimal | Unknown | 34 | 2.11 | Female | 2 | ZDV/3 doses NVP |
6 | Intrapartum | NA | NA | 50–999 | 40 | 2.97 | Male | 10 | ZDV/3TC/3 doses NVP |
7 | Intrapartum | NA | NA | Unknown | 39 | 2.76 | Male | 2 | ZDV/3TC/NVP |
8 | Intrapartum | NA | NA | Unknown | 33 | 1.75 | Female | 1 | ZDV/1 dose NVP |
9 | Intrapartum | NA | NA | ≥ 1000 | 35 | 1.75 | Female | 1 | ZDV/3TC/NVP |
10 | Intrapartum | NA | NA | ≥ 1000 | 39 | 2.76 | Male | 2 | ZDV/3TC/NFV‡ |
11 | After delivery | NA | NA | Unknown | 39 | 3.00 | Female | 129 | None |
12 | After delivery | NA | NA | Unknown | 41 | Unknown | Male | 122 | None |
13 | After delivery | NA | NA | Unknown | 37 | 3.40 | Male | 264 | None |
14 | After delivery | NA | NA | Unknown | 40 | 2.88 | Female | 484 | None |
Note: 3TC = lamivudine, NA = not applicable, NFV = nelfinavir, NVP = nevirapine, PCR = polymerase chain reaction, ZDV = zidovudine.
↵* Mode of delivery was spontaneous vaginal delivery except in cases 1, 12 and 13 (elective cesarean birth).
↵† All medications were administered at treatment dosages except where noted otherwise.
↵‡ Also received 3 doses of nevirapine during first week of life.