Baseline characteristics of Clostridioides difficile infection cohorts in Ontario, 2005/06–2014/15, stratified by association and onset*
| Characteristic | No. (%) of patients† | ||||||
|---|---|---|---|---|---|---|---|
| ACH-associated/ACH-onset n = 17 272 | ACH- or LTCF-associated/ACH-onset n = 842 | LTCF-associated/LTCF-onset n = 544 | LTCF- or ACH-associated/LTCF-onset n = 937 | Community-associated/community-onset n = 7216 | ACH-associated/community-onset n = 7098 | All n = 33 909 | |
| Patient days, mean ± SD | 49.00 ± 64.69 | 33.66 ± 46.46 | 13.89 ± 19.53 | 13.44 ± 14.68 | 20.63 ± 34.27 | 21.54 ± 38.35 | 35.29 ± 54.37 |
| Age at index date, yr, mean ± SD | 72.22 ± 15.29 | 81.43 ± 9.67 | 84.57 ± 8.48 | 82.14 ± 9.99 | 70.07 ± 17.78 | 71.48 ± 15.77 | 72.31 ± 15.90 |
| Age group, yr | |||||||
| 18–44 | 1005 (5.8) | 1–5‡ | 1–5‡ | 4–8‡ | 728 (10.1) | 486 (6.8) | 2227 (6.6) |
| 45–64 | 3516 (20.4) | 46–50‡ | 7–11‡ | 45–49‡ | 1578 (21.9) | 1485 (20.9) | 6687 (19.7) |
| 65–74 | 3576 (20.7) | 118 (14.0) | 48 (8.8) | 116 (12.4) | 1330 (18.4) | 1474 (20.8) | 6662 (19.6) |
| 75–84 | 5458 (31.6) | 296 (35.2) | 174 (32.0) | 337 (36.0) | 1946 (27.0) | 2197 (31.0) | 10 408 (30.7) |
| ≥ 85 | 3717 (21.5) | 377 (44.8) | 310 (57.0) | 431 (46.0) | 1634 (22.6) | 1456 (20.5) | 7925 (23.4) |
| Sex | |||||||
| Female | 8735 (50.6) | 504 (59.9) | 356 (65.4) | 585 (62.4) | 4305 (59.7) | 3880 (54.7) | 18 365 (54.2) |
| Male | 8537 (49.4) | 338 (40.1) | 188 (34.6) | 352 (37.6) | 2911 (40.3) | 3218 (45.3) | 15 544 (45.8) |
| Admitted within 90 d before onset | 5909 (34.2) | 481 (57.1) | 13 (2.4) | 937 (100.0) | 132 (1.8) | 7098 (100.0) | 14 570 (43.0) |
| Antibiotic use in 30 d before onset* | 4216 (24.4) | 342 (40.6) | 147 (27.0) | 512 (54.6) | 1570 (21.8) | 3212 (45.3) | 9999 (29.5) |
| Comorbidities | |||||||
| Cardiovascular disease | 10 771 (62.4) | 663 (78.7) | 378 (69.5) | 794 (84.7) | 3935 (54.5) | 5045 (71.1) | 21 586 (63.7) |
| Chronic obstructive pulmonary disease | 2057 (11.9) | 114 (13.5) | 77 (14.2) | 148 (15.8) | 771 (10.7) | 1104 (15.6) | 4271 (12.6) |
| Congestive heart failure | 3076 (17.8) | 205 (24.3) | 108 (19.9) | 286 (30.5) | 998 (13.8) | 1567 (22.1) | 6240 (18.4) |
| Diabetes | 1590 (9.2) | 100 (11.9) | 60 (11.0) | 92 (9.8) | 583 (8.1) | 775 (10.9) | 3200 (9.4) |
| Renal disease | 3682 (21.3) | 212 (25.2) | 98 (18.0) | 270 (28.8) | 1277 (17.7) | 1839 (25.9) | 7378 (21.8) |
| Liver disease | 1311 (7.6) | 52 (6.2) | 26 (4.8) | 55 (5.9) | 474 (6.6) | 686 (9.7) | 2604 (7.7) |
| Cancer | 3249 (18.8) | 76 (9.0) | 28 (5.1) | 84 (9.0) | 924 (12.8) | 1668 (23.5) | 6029 (17.8) |
| Pulmonary circulation disease | 634 (3.7) | 44 (5.2) | 20 (3.7) | 46 (4.9) | 197 (2.7) | 405 (5.7) | 1346 (4.0) |
| Valvular disease | 986 (5.7) | 53 (6.3) | 16 (2.9) | 73 (7.8) | 242 (3.4) | 462 (6.5) | 1832 (5.4) |
| Inflammatory bowel disease | 605 (3.5) | 16 (1.9) | 14 (2.6) | 35 (3.7) | 640 (8.9) | 537 (7.6) | 1847 (5.4) |
| Hospital characteristics | |||||||
| Location | |||||||
| Urban | 16 726 (96.8) | 823 (97.7) | 524 (96.3) | 916 (97.8) | 6802 (94.3) | 6624 (93.3) | 32 415 (95.6) |
| Rural | 546 (3.2) | 19 (2.3) | 20 (3.7) | 21 (2.2) | 414 (5.7) | 474 (6.7) | 1494 (4.4) |
| No. of beds | |||||||
| < 100 | 1682 (9.7) | 79 (9.4) | 87 (16.0) | 114 (12.2) | 1155 (16.0) | 1232 (17.4) | 4349 (12.8) |
| 100–299 | 7026 (40.7) | 409 (48.6) | 279 (51.3) | 430 (45.9) | 3118 (43.2) | 3037 (42.8) | 14 299 (42.2) |
| 300–499 | 6395 (37.0) | 282 (33.5) | 144 (26.5) | 312 (33.3) | 2221 (30.8) | 2130 (30.0) | 11 484 (33.9) |
| ≥ 500 | 2169 (12.6) | 72 (8.6) | 34 (6.3) | 81 (8.6) | 722 (10.0) | 699 (9.8) | 3777 (11.1) |