Crude and adjusted hazard ratios for all outcomes, direct oral anticoagulants versus warfarin
| Outcome | HR (95% CI) | |
|---|---|---|
| Crude* | Adjusted† | |
| Ischemic stroke or systemic embolization | 0.88 (0.80 to 0.97) | 1.02 (0.87 to 1.20) |
| Major bleeding | 0.81 (0.72 to 0.92) | 0.81 (0.69 to 0.97) |
| Composite of ischemic stroke or systemic embolization, major bleeding, and all-cause mortality | 0.78 (0.73 to 0.84) | 0.81 (0.74 to 0.89) |
| Myocardial infarction | 0.92 (0.83 to 1.02) | 0.96 (0.84 to 1.09) |
| Intracranial bleeding | 0.62 (0.54 to 0.71) | 0.55 (0.45 to 0.66) |
| Gastrointestinal bleeding | 0.98 (0.89 to 1.07) | 1.00 (0.88 to 1.15) |
| All-cause mortality | 0.74 (0.70 to 0.78) | 0.81 (0.78 to 0.85) |