Pooled cumulative incidence and incidence difference per 1000 patients at 1 year for individual components of the primary and secondary outcomes
| Outcome | Group; 1-year cumulative incidence per 1000 patients (95% CI) | Incidence difference (95% CI) | |
|---|---|---|---|
| DOAC | Warfarin | ||
| Ischemic stroke or systemic embolization | 7.71 (5.67 to 9.75) | 8.88 (5.22 to 12.54) | −1.56 (−2.79 to −0.33) |
| Major bleeding | 35.97 (23.60 to 48.34) | 41.86 (21.23 to 62.49) | −6.16 (−13.55 to 1.22) |
| Intracranial bleeding | 2.84 (1.87 to 3.81) | 4.10 (1.58 to 6.62) | −1.25 (−2.32 to −0.17) |
| Gastrointestinal bleeding | 19.00 (14.11 to 23.90) | 15.49 (8.99 to 21.98) | 1.08 (−0.72 to 2.88) |
| Myocardial infarction | 7.50 (5.55 to 9.36) | 7.40 (3.47 to 11.32) | −0.29 (−1.42 to 0.83) |
| All-cause mortality | 54.00 (37.91 to 70.09) | 65.64 (47.16 to 84.12) | −13.79 (−21.59 to −5.98) |
Note: CI = confidence interval, DOAC = direct oral anticoagulant.