Health state | Entry criterion/criteria |
---|---|
No cirrhosis | First date of confirmed diagnosis of chronic hepatitis C with positive HCV RNA or HCV antibody test result recorded* |
No cirrhosis (RNA negative) | Patient receives negative RNA test result and has no liver disease (CC, DC or HCC) |
Compensated cirrhosis | Patient is diagnosed with cirrhosis, or 5 yr before day patient is diagnosed with DC† |
Decompensated cirrhosis | Patient is diagnosed with DC‡ |
Hepatocellular carcinoma | Patient is diagnosed with HCC§ |
Both decompensated cirrhosis and hepatocellular carcinoma | Patient is diagnosed with HCC while already having DC diagnosis, or is diagnosed with DC while already having HCC diagnosis |
Liver transplantation | Patient receives LT during observation period |
Terminal, liver-related | 6 mo before day of death in patient with advanced liver disease (DC, HCC or LT) |
Terminal, non–liver- related | 6 mo before day of death in patient without advanced liver disease |
Note: CC = compensated cirrhosis, DC = decompensated cirrhosis, HCC = hepatocellular carcinoma, HCV = hepatitis C virus, LR = liver-related, LT = liver transplantation, NLR = non–liver-related.
↵* See Appendix 1, Supplemental Table S1 for detailed cases definition.
↵† See Appendix 1, Supplemental Table S2 for detailed cases definition.
↵‡ See Appendix 1, Supplemental Table S3 for detailed cases definition.
↵§ See Appendix 1, Supplemental Table S4 for detailed cases definition.