Accuracy parameters of case definitions in the British Columbia node of the Canadian Primary Care Sentinel Surveillance Network
| Definition | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) |
|---|---|---|---|---|
| 1.1. MaRNet-FP 1 ICD-9 code OR ACEI/ARB + BB + diuretic | 90.3 (81.0–96.0) | 93.3 (89.4–96.1) | 80.2 (69.9–88.3) | 97.0 (93.8–98.8) |
| 1.2. MaRNet-FP Including billings | 93.1 (84.5–97.7) | 90.8 (86.4–94.1) | 75.3 (65.0–83.8) | 97.7 (94.8–99.3) |
| Expanding codes and testing iterations and specific combinations (BC group 1) | ||||
| 2.1. One expanded code AND specific medication | 75.0 (63.4–84.5) | 92.9 (88.9–95.8) | 76.1 (64.5–85.4) | 92.5 (88.4–95.5) |
| 2.2. One expanded code only | 91.7 (82.7–96.9) | 91.2 (86.9–94.5) | 75.9 (65.5–84.4) | 97.3 (94.4–99.0) |
| 2.3. Two expanded codes | 83.3 (72.7–91.1) | 94.6 (90.9–97.1) | 82.2 (71.5–90.2) | 95.0 (91.4–97.4) |
| 2.4. Specific medication only | 18.1 (10.0–91.1) | 99.6 (97.7,100.0) | 92.9 (66.1–99.8) | 80.1 (75.1–84.5) |
| 2.5. (2.1. or 2.3. or 2.4) | 87.5 (77.6–94.1) | 92.1 (87.9–95.1) | 76.8 (66.2–85.4) | 96.1 (92.7–98.2) |
| Addition of furosemide (BC group 2) | ||||
| 3.1. (2.1. OR furosemide) | 80.6 (69.5–88.9) | 94.1 (90.4–96.8) | 80.6 (69.5–88.9) | 94.1 (90.4–96.8) |
| 3.2. (3.1. including billing) | 90.3 (81.0–96.0) | 91.6 (87.4–94.8) | 76.5 (66.0–85.0) | 96.9 (93.7–98.7) |
| Including low-threshold NP | ||||
| 4.1. (1.1. OR low-threshold NP) | 93.1 (84.5–97.7) | 88.7 (84.0–92.4) | 71.3 (61.0–80.1) | 97.7 (94.7–99.2) |
| 4.2. (1.2. OR low-threshold NP) | 94.4 (86.4–98.5) | 87.0 (82.1–91.0) | 68.7 (58.6–77.6) | 98.1 (95.2–99.5) |
| 4.3. (3.2. OR low-threshold NP) | 93.1 (84.5–97.7) | 87.0 (82.1–91.0) | 68.4 (58.2–77.4) | 97.7 (94.6–99.2) |
| Including high-threshold NP | ||||
| 5.1. (1.1 OR high-threshold NP) | 91.7 (82.7–96.9) | 92.9 (88.9–95.8) | 79.5 (69.2–87.6) | 97.4 (94.4–99.0) |
| 5.2. (1.2 OR high-threshold NP) | 93.1 (84.5–97.7) | 90.8 (86.4–94.1) | 75.3 (65.0–83.8) | 97.7 (94.8–99.3) |
| 5.3. (3.2 OR high-threshold NP) | 90.3 (81.0–96.0) | 91.6 (87.4–94.8) | 76.5 (66.0–85.0) | 96.9 (93.7–98.7) |
Note: ACEI = angiotensin-converting-enzyme inhibitor, ARB = angiotensin II receptor blocker, BB = β-blocker, BC = British Columbia, CI = confidence interval, MARNet-FP = Maritime Family Practice Research Network, NP = natriuretic peptide, NPV = negative predictive value, PPV = positive predictive value.