Interaction of all-trans-retinoic acid with fluconazole in acute promyelocytic leukemia

J Pediatr Hematol Oncol. 2003 May;25(5):403-4. doi: 10.1097/00043426-200305000-00010.

Abstract

All-trans-retinoic acid (ATRA) has a dramatic antitumor effect in patients with acute promyelocytic leukemia (APL). It is hepatically metabolized by cytochrome P-450, and there are known toxicities associated with high levels of this drug. The effects of ATRA can be potentiated by inhibition of cytochrome P-450, which is known to occur with certain drugs. We report a case of a patient with ATRA toxicity thought to be secondary to interaction with fluconazole.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Cytochrome P-450 Enzyme System / metabolism
  • Drug Interactions
  • Female
  • Fluconazole / adverse effects*
  • Fluconazole / therapeutic use*
  • Humans
  • Leukemia, Promyelocytic, Acute / drug therapy*
  • Leukemia, Promyelocytic, Acute / metabolism*
  • Male
  • Tretinoin / adverse effects*
  • Tretinoin / therapeutic use*

Substances

  • Tretinoin
  • Fluconazole
  • Cytochrome P-450 Enzyme System