Objective. —To further define the safety and efficacy of recombinant human interleukin 1
receptor antagonist (rhIL-1ra) in the treatment of sepsis syndrome. Study Design. —Randomized…

Background: The provision of nutritional support for patients in intensive care units (ICUs)
varies widely both within and between institutions. We tested the hypothesis that evidence-…

Early mobilization of critically ill patients is beneficial, suggesting that it should be incorporated
into daily clinical practice. Early passive, active, and combined progressive mobilizations …

… Keenan, Martin, and Sibbald) and Respiratory Medicine (Drs. Keenan, and McCormack),
Department of Medicine, University of Western Ontario, London Health Sciences Centre …

Background: Previous studies have suggested that a patient's sex may influence the provision
and outcomes of critical care. Our objective was to determine whether sex and age are …

Objective: To determine the location of acquisition, timing, and outcomes associated with
severe sepsis in community and teaching hospital critical care units. Design: Prospective, …

Objective: Prolonged stay in the intensive care unit (ICU) is associated with high mortality,
morbidity, and costs. Identifying those patients who are most likely to benefit from an extended …

ContextRenal dysfunction is a complication of coronary artery bypass graft (CABG) surgery
performed with cardiopulmonary bypass (CPB) that is associated with increased morbidity …

… Chen, Martin, Keenan, and Sibbald); and the Canadian Lung Association, Medical
Research Council of Canada Fellowship (Dr. Keenan), London, ON, Canada. … Address …

Translocation of bacteria and endotoxin leading to sepsis occurs in animals subjected to
burns or intestinal ischemia. This may be mediated in part by bowel mucosal microcirculatory …