Acute myeloid leukemia (AML) is a cancer of myeloid-lineage cells with limited therapeutic
options. We previously combined ex vivo drug sensitivity with genomic, transcriptomic, and …

The most momentous natural disasters are not necessarily those with the most victims, but
rather those producing the greatest shockwaves in intellectual history. The Lisbon earthquake …

Background People with chronic diseases experience barriers to managing their diseases
and accessing available health services. Patient navigator programs are increasingly being …

Chronic myeloid leukemia (CML), caused by constitutively active BCR-ABL1 fusion tyrosine
kinase, has served as a paradigm for successful application of molecularly targeted cancer …

Palliative sedation is an effective symptom control strategy for patients who suffer from
intractable symptoms at the end of life. Evidence suggests that the use of this practice varies …

Glucocorticoids are highly conserved fundamental regulators of energy homeostasis. In
response to stress in the form of perceived danger or acute inflammation, glucocorticoids are …

Background: De-institutionalization of health care services provided to terminally ill cancer
patients is a cost-effective strategy that underpins health care reforms in Canada. The …

Skeletal muscle catabolism is a co-morbidity of many chronic diseases and is the result of
systemic inflammation. Although direct inflammatory cytokine action on muscle promotes …

The characterization of cancer genomes has provided insight into somatically altered genes
across tumors, transformed our understanding of cancer biology, and enabled tailoring of …

In response to illness, animals subvert normal homeostasis and divert their energy utilization
to fight infection. An important and unexplored feature of this response is the suppression of …