Changes in gut microbiota have been associated with several diseases. Here, the International
Multiple Sclerosis Microbiome Study (iMSMS) studied the gut microbiome of 576 MS …

We aimed to increase our understanding of the genetic determinants of vitamin D levels by
undertaking a large-scale genome-wide association study (GWAS) of serum 25 …

Patients with temporal lobe epilepsy (TLE) are refractory to antiepileptic drugs in about 30%
of cases. Surgical treatment has been shown to be beneficial for the selected patients but …

Background Infectious diseases are causally related to a large array of noncommunicable
diseases (NCDs). Identifying genetic determinants of infections and antibody-mediated …

Autoimmune diseases display a high degree of comorbidity within individuals and families,
suggesting shared risk factors. Over the past 15 years, genome-wide association studies …

The etiology of multiple sclerosis (MS) involves a complex interplay of genetic and environmental
factors. Epidemiologic studies have furthered our understanding of these risk factors …

Background Vitamin D deficiency has been associated with type 1 diabetes in observational
studies, but evidence from randomized controlled trials (RCTs) is lacking. The aim of this …

Motivation Knowledge graphs (KGs) are being adopted in industry, commerce and academia.
Biomedical KG presents a challenge due to the complexity, size and heterogeneity of the …

Purpose Global sagittal alignment is considered as an important aspect in the management
of spinal disorders, but the evidence establishing its clinical impact in lumbosacral …

Polygenic inheritance plays a pivotal role in driving multiple sclerosis susceptibility, an
inflammatory demyelinating disease of the CNS. We developed polygenic risk scores (PRS) of …