[HTML][HTML] A population-based study of the drug interaction between proton pump inhibitors and clopidogrel
Background: Most proton pump inhibitors inhibit the bioactivation of clopidogrel to its active
metabolite. The clinical significance of this drug interaction is unknown. Methods: We …
metabolite. The clinical significance of this drug interaction is unknown. Methods: We …
Cyclo-oxygenase-2 inhibitors versus non-selective non-steroidal anti-inflammatory drugs and congestive heart failure outcomes in elderly patients: a population …
Background Non-selective, non-steroidal anti-inflammatory drugs (NSAIDs) are associated
with an increased risk of congestive heart failure, but little is known about the cardiovascular …
with an increased risk of congestive heart failure, but little is known about the cardiovascular …
Prescribing of opioid analgesics and related mortality before and after the introduction of long-acting oxycodone
IA Dhalla, MM Mamdani, MLA Sivilotti, A Kopp… - Cmaj, 2009 - Can Med Assoc
Introduction: Opioid-related mortality appears to be increasing in Canada. We examined the
true extent of the problem and the impact of the introduction of long-acting oxycodone. …
true extent of the problem and the impact of the introduction of long-acting oxycodone. …
[HTML][HTML] Rates of hyperkalemia after publication of the Randomized Aldactone Evaluation Study
…, MM Mamdani, DS Lee, A Kopp… - … England Journal of …, 2004 - Mass Medical Soc
Background The Randomized Aldactone Evaluation Study (RALES) demonstrated that
spironolactone significantly improves outcomes in patients with severe heart failure. Use of …
spironolactone significantly improves outcomes in patients with severe heart failure. Use of …
Shifts in office and virtual primary care during the early COVID-19 pandemic in Ontario, Canada
BACKGROUND: Globally, primary care changed dramatically as a result of the coronavirus
disease 2019 (COVID-19) pandemic. We aimed to understand the degree to which office and …
disease 2019 (COVID-19) pandemic. We aimed to understand the degree to which office and …
Observational study of upper gastrointestinal haemorrhage in elderly patients given selective cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti …
M Mamdani, PA Rochon, DN Juurlink, A Kopp… - Bmj, 2002 - bmj.com
Objective: To compare rates of upper gastrointestinal haemorrhage among elderly patients
given selective cyclo-oxygenase-2 (COX 2) inhibitors and non-selective non-steroidal anti-…
given selective cyclo-oxygenase-2 (COX 2) inhibitors and non-selective non-steroidal anti-…
Effect of selective cyclooxygenase 2 inhibitors and naproxen on short-term risk of acute myocardial infarction in the elderly
…, DN Juurlink, GM Anderson, A Kopp… - Archives of internal …, 2003 - jamanetwork.com
Background Recent debate has emerged regarding the cardiovascular safety of selective
cyclooxygenase 2 inhibitors and the possible cardioprotective effect of naproxen sodium. We …
cyclooxygenase 2 inhibitors and the possible cardioprotective effect of naproxen sodium. We …
Drug-drug interactions among elderly patients hospitalized for drug toxicity
DN Juurlink, M Mamdani, A Kopp, A Laupacis… - Jama, 2003 - jamanetwork.com
ContextDrug-drug interactions are a preventable cause of morbidity and mortality, yet their
consequences in the community are not well characterized.ObjectiveTo determine whether …
consequences in the community are not well characterized.ObjectiveTo determine whether …
Living near major roads and the incidence of dementia, Parkinson's disease, and multiple sclerosis: a population-based cohort study
…, RV Martin, BJ Murray, B Jessiman, AS Wilton, A Kopp… - The Lancet, 2017 - thelancet.com
Background Emerging evidence suggests that living near major roads might adversely
affect cognition. However, little is known about its relationship with the incidence of dementia, …
affect cognition. However, little is known about its relationship with the incidence of dementia, …
Medical illness and the risk of suicide in the elderly
…, N Herrmann, JP Szalai, A Kopp… - Archives of internal …, 2004 - jamanetwork.com
Background Suicide is a leading cause of death, and rates are especially high among the
elderly. Medical illnesses may predispose to suicide, but few controlled studies have …
elderly. Medical illnesses may predispose to suicide, but few controlled studies have …