Rituximab for the treatment of patients with autoimmune hepatitis who are refractory or intolerant to standard therapy

…, SS Lee, SJ Urbanski, AI Aspinall… - Canadian Journal of …, 2013 - hindawi.com
BACKGROUND: Although most patients with autoimmune hepatitis (AIH) respond to treatment
with prednisone and/or azathioprine, some patients are intolerant or refractory to standard …

Gender, renal function, and outcomes on the liver transplant waiting list: assessment of revised MELD including estimated glomerular filtration rate

RP Myers, AAM Shaheen, AI Aspinall, RR Quinn… - Journal of …, 2011 - Elsevier
BACKGROUND & AIMS: The Model for End-Stage Liver Disease (MELD) allocation system
for liver transplantation (LT) may present a disadvantage for women by including serum …

[PDF][PDF] CX3CR1 and vascular adhesion protein‐1‐dependent recruitment of CD16+ monocytes across human liver sinusoidal endothelium

AI Aspinall, SM Curbishley, PF Lalor, CJ Weston… - …, 2010 - Wiley Online Library
The liver contains macrophages and myeloid dendritic cells (mDCs) that are critical for the
regulation of hepatic inflammation. Most hepatic macrophages and mDCs are derived from …

Gut homing receptors on CD8 T cells are retinoic acid dependent and not maintained by liver dendritic or stellate cells

…, EJ Villablanca, SM Curbishley, AI Aspinall… - Gastroenterology, 2009 - Elsevier
BACKGROUND & AIMS: Lymphocytes primed by intestinal dendritic cells (DC) express the
gut-homing receptors CCR9 and α4β7, which recognize CCL25 and mucosal addressin cell-…

[HTML][HTML] Revision of MELD to include serum albumin improves prediction of mortality on the liver transplant waiting list

RP Myers, AAM Shaheen, P Faris, AI Aspinall… - PloS one, 2013 - journals.plos.org
Background Allocation of donor livers for transplantation in most regions is based on the
Model for End-Stage Liver Disease (MELD) or MELD-sodium (MELDNa). Our objective was to …

Lack of chemokine receptor CCR5 promotes murine fulminant liver failure by preventing the apoptosis of activated CD1d-restricted NKT cells

MN Ajuebor, AI Aspinall, F Zhou, T Le… - The Journal of …, 2005 - journals.aai.org
Fulminant liver failure (FLF) consists of a cascade of events beginning with a presumed
uncontrolled systemic activation of the immune system. The etiology of FLF remains undefined. …

Validation of the five‐variable Model for End‐stage Liver Disease (5vMELD) for prediction of mortality on the liver transplant waiting list

…, P Faris, AAM Shaheen, AI Aspinall… - Liver …, 2014 - Wiley Online Library
Background Modifications to the Model for End‐Stage Liver Disease ( MELD ) have been
proposed to improve prioritization of liver transplant ( LT ) candidates. Using a US database, …

Blue rubber bleb nevus syndrome

PL Beck, AI Aspinall, VM Kilvert, J Dort - Gastrointestinal endoscopy, 2002 - giejournal.org
Discussion The most common presentations of BRBNS are either the appearance of the skin
lesions alone or iron deficiency anemia. Most patients with GI bleeding are asymptomatic …

Real-world treatment of hepatitis C with second-generation direct-acting antivirals: initial results from a multicentre Canadian retrospective cohort of diverse patients

AI Aspinall, AA Shaheen, GS Kochaksaraei… - … Open Access Journal, 2018 - cmajopen.ca
… Abdel Shaheen and Alex Aspinall interpreted the data. Alex Aspinall drafted the manuscript,
and Alex Aspinall, Abdel Shaheen and Carla Coffin revised it critically for important …

Hepatitis B virus testing and linkage to care in a Canadian urban tertiary referral centre: a retrospective cohort study

KCK Lau, AA Shaheen, AA Aspinall… - … Open Access Journal, 2017 - cmajopen.ca
Background: Despite universal vaccination, chronic hepatitis B virus (HBV) infection remains
a public health concern in North America owing to immigration. We aimed to characterize …