Use of LCA as a development tool within early research: challenges and issues across different sectors
AC Hetherington, AL Borrion, OG Griffiths… - … International Journal of …, 2014 - Springer
Purpose The aim of this paper is to highlight the challenges that face the use of life cycle
assessment (LCA) for the development of emerging technologies. LCA has great potential for …
assessment (LCA) for the development of emerging technologies. LCA has great potential for …
[HTML][HTML] Differential lipotoxic effects of palmitate and oleate in activated human hepatic stellate cells and epithelial hepatoma cells
AM Hetherington, CG Sawyez, E Zilberman… - Cellular Physiology and …, 2016 - karger.com
Background/Aims: Nonalcoholic fatty liver disease (NAFLD) progression to fibrosis, cirrhosis
and hepatocellular carcinoma, alters the cellular composition of this organ. During late-…
and hepatocellular carcinoma, alters the cellular composition of this organ. During late-…
[HTML][HTML] The marine compound and elongation factor 1A1 inhibitor, didemnin B, provides benefit in western diet-induced non-alcoholic fatty liver disease
…, R Zhang, T Woolnough, AM Hetherington… - Pharmacological …, 2020 - Elsevier
Inhibition of eukaryotic elongation factor 1A1 (EEF1A1) with the marine compound didemnin
B decreases lipotoxic HepG2 cell death in vitro and improves early stage non-alcoholic fatty …
B decreases lipotoxic HepG2 cell death in vitro and improves early stage non-alcoholic fatty …
[HTML][HTML] Elongation factor 1A-1 is a mediator of hepatocyte lipotoxicity partly through its canonical function in protein synthesis
AM Stoianov, DL Robson, AM Hetherington… - PloS one, 2015 - journals.plos.org
Elongation factor 1A-1 (eEF1A-1) has non-canonical functions in regulation of the actin
cytoskeleton and apoptosis. It was previously identified through a promoter-trap screen as a …
cytoskeleton and apoptosis. It was previously identified through a promoter-trap screen as a …
MBSAQIP risk calculator use in bariatric surgery is associated with a reduction in serious complications: a retrospective analysis of 210,710 patients
A Hetherington, K Verhoeff, V Mocanu, DW Birch… - Surgery for Obesity and …, 2023 - Elsevier
Background The Metabolic and Bariatric Accreditation and Quality Improvement Program (MBSAQIP)
Bariatric Surgical Risk/Benefit Calculator was developed to provide patient-specific …
Bariatric Surgical Risk/Benefit Calculator was developed to provide patient-specific …
Treatment with didemnin B, an elongation factor 1A inhibitor, improves hepatic lipotoxicity in obese mice
AM Hetherington, CG Sawyez… - Physiological …, 2016 - Wiley Online Library
Eukaryotic elongation factor EEF 1A1 is induced by oxidative and ER stress, and contributes
to subsequent cell death in many cell types, including hepatocytes. We recently showed …
to subsequent cell death in many cell types, including hepatocytes. We recently showed …
Liver trauma in the intensive care unit
A Hetherington, FS Cardoso, ELW Lester… - Current Opinion in …, 2022 - journals.lww.com
… Articles in PubMed by Alexandra Hetherington Articles in Google Scholar by Alexandra
Hetherington Other articles in this journal by Alexandra Hetherington …
Hetherington Other articles in this journal by Alexandra Hetherington …
Organ donation in trauma victims: A systematic review and meta-analysis
…, M Erdogan, S Lanteigne, A Hetherington… - Journal of Trauma …, 2018 - journals.lww.com
BACKGROUND Although trauma patients represent a large pool of potential organ donors (PODs),
the donor conversion rates (DCRs) in this population are unclear. Our primary …
the donor conversion rates (DCRs) in this population are unclear. Our primary …
Factors associated with organ donation by trauma patients in Nova Scotia
A Hetherington, M Erdogan, A Cameron… - Journal of Trauma …, 2020 - journals.lww.com
BACKGROUND Trauma patients represent a significant pool of potential organ donors (PODs),
and previous research suggests that this population is underutilized for organ donation (…
and previous research suggests that this population is underutilized for organ donation (…
Organ donation by patients with and without trauma in a Canadian province: a retrospective cohort analysis
S Lanteigne, M Erdogan, A Hetherington… - … Open Access Journal, 2018 - cmajopen.ca
Background: People who experience trauma represent a large pool of potential organ donors.
Our objective was to describe organ donation by patients with and without trauma in Nova …
Our objective was to describe organ donation by patients with and without trauma in Nova …