MYC dysregulation initiates a dynamic process of genomic instability that is linked to tumor
initiation. Early studies using MYC-carrying retroviruses showed that these viruses were …

Physician–scientists are individuals who actively participate in patient care, have undergone
additional research training, and devote the majority of their time to research. Physician–…

Aging is the decline of physiological capabilities required for life maintenance and reproduction
over time. The human immune cells, including T-cells lymphocytes, undergo dramatic …

Amyloid peptide (Aβ) aggregation in the brain is a characteristic feature of Alzheimer disease
(AD). Previously, we reported the discovery of focally elevated creatine deposits in brain …

Multiple myeloma (MM) is preceded by monoclonal gammopathy of undetermined significance
(MGUS). Up to date, it is difficult to predict an individual's time to disease progression and …

Using 3D telomere quantitative fluorescence in situ hybridization, we determined the 3D
telomere organization of 74 neuroblastoma tissue samples. Hierarchical cluster analysis of the …

Background: Combined MD/PhD programs provide a structured path for physician-scientist
training, but assessment of their success within Canada is limited by a lack of quantitative …

Clinician-scientists are physicians with training in both clinical medicine and research that
enables them to occupy a unique niche as specialists in basic and translational biomedical …

MYCN amplification and MYCN overexpression are poor prognostic factors in neuroblastoma.
Tumors with unbalanced chromosome arm 17q gain are often associated with MYCN …

The vibrational spectra of molecules contain a wealth of information, if only one can find the
key. Our current efforts are directed towards interpretation of spatially resolved IR, Raman …