Objective: Procalcitonin may be associated with reduced antibiotic usage compared to
usual care. However, individual randomized controlled trials testing this hypothesis were too …

Objectives To determine hospital incidence, mortality, and management for thoracic aortic
dissections and aneurysms. Methods A population-based retrospective cohort study of …

Background The “obesity paradox” reflects an observed relationship between obesity and
decreased morbidity and mortality, suggesting improved health outcomes for obese individuals…

Background Direct oral anticoagulants (DOACs) have expanded the armamentarium for
antithrombotic therapy. Although DOAC-related major bleeding was associated with favorable …

Objective To assess the efficacy of a programme of supervised physiotherapy on the
recovery of simple grade 1 and 2 ankle sprains. Design A randomised controlled trial of 503 …

Background The clinical armamentarium for anticoagulation has expanded substantially since
the recent approval of dabigatran, rivaroxaban and apixaban for the prevention of stroke …

Worldwide, more than 230 million adults have major noncardiac surgery each year. Although
surgery can improve quality and duration of life, it can also precipitate major complications. …

Objectives: This study describes the development of a framework for health technology
decisions, for Ontario Health Technology Advisory Committee (OHTAC) in Ontario, Canada.…

Background Thoracic aortic dissections ( TADs ) and thoracic aortic aneurysms ( TAAs ) are
resource intensive. We sought to determine economic burden and healthcare resource use …

Background Ankle and foot sprains and fractures are prevalent injuries, which may result in
substantial physical and economic consequences for the patient and place a financial …