[HTML][HTML] Scar wars: mapping the fate of epithelial–mesenchymal–myofibroblast transition
SE Quaggin, A Kapus - Kidney international, 2011 - Elsevier
The hypothesis that epithelial–mesenchymal transition (EMT) might be a contributor to the
accumulation of fibroblasts and myofibroblasts (MFs) in the kidney during fibrogenesis was …
accumulation of fibroblasts and myofibroblasts (MFs) in the kidney during fibrogenesis was …
Integrity of cell-cell contacts is a critical regulator of TGF-β1-induced epithelial-to-myofibroblast transition: role for β-catenin
…, CA McCulloch, OD Rotstein, I Mucsi, A Kapus - The American journal of …, 2004 - Elsevier
Injury of the tubular epithelium and TGF-β1-induced conversion of epithelial cells to α-smooth
muscle actin (SMA)-expressing myofibroblasts are key features of kidney fibrosis. Since …
muscle actin (SMA)-expressing myofibroblasts are key features of kidney fibrosis. Since …
Receptor activation alters inner surface potential during phagocytosis
The surface potential of biological membranes varies according to their lipid composition.
We devised genetically encoded probes to assess surface potential in intact cells. These …
We devised genetically encoded probes to assess surface potential in intact cells. These …
Membrane phosphatidylserine regulates surface charge and protein localization
T Yeung, GE Gilbert, J Shi, J Silvius, A Kapus… - Science, 2008 - science.org
Electrostatic interactions with negatively charged membranes contribute to the subcellular
targeting of proteins with polybasic clusters or cationic domains. Although the anionic …
targeting of proteins with polybasic clusters or cationic domains. Although the anionic …
Cortactin: the gray eminence of the cytoskeleton
LI Cosen-Binker, A Kapus - Physiology, 2006 - journals.physiology.org
Cortactin, an actin filament-binding protein and target of multiple kinases, has emerged as a
central element connecting signaling pathways with cytoskeleton restructuring. It is involved …
central element connecting signaling pathways with cytoskeleton restructuring. It is involved …
Force activates smooth muscle α-actin promoter activity through the Rho signaling pathway
…, P Arora, K Szászi, A Kapus… - Journal of cell …, 2007 - journals.biologists.com
In pressure or volume overload, hypertrophic growth of the myocardium is associated with
myofibroblast differentiation, a process in which cardiac fibroblasts express smooth muscle α-…
myofibroblast differentiation, a process in which cardiac fibroblasts express smooth muscle α-…
[HTML][HTML] Pre–B cell colony–enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis
SH Jia, Y Li, J Parodo, A Kapus, L Fan… - The Journal of …, 2004 - Am Soc Clin Investig
Pre–B cell colony-enhancing factor (PBEF) is a highly conserved 52-kDa protein, originally
identified as a growth factor for early stage B cells. We show here that PBEF is also …
identified as a growth factor for early stage B cells. We show here that PBEF is also …
Cell contact–dependent regulation of epithelial–myofibroblast transition via the rho-rho kinase-phospho-myosin pathway
Epithelial-mesenchymal-myofibroblast transition (EMT), a key feature in organ fibrosis, is
regulated by the state of intercellular contacts. Our recent studies have shown that an initial …
regulated by the state of intercellular contacts. Our recent studies have shown that an initial …
Oxidative stress generated by hemorrhagic shock recruits Toll-like receptor 4 to the plasma membrane in macrophages
…, PS Tawadros, JC Marshall, A Kapus… - The Journal of …, 2006 - rupress.org
Oxidative stress generated by ischemia/reperfusion is known to prime inflammatory cells for
increased responsiveness to subsequent stimuli, such as lipopolysaccharide (LPS). The …
increased responsiveness to subsequent stimuli, such as lipopolysaccharide (LPS). The …
Central role for Rho in TGF-β1-induced α-smooth muscle actin expression during epithelial-mesenchymal transition
…, L Rosivall, I Mucsi, A Kapus - American Journal …, 2003 - journals.physiology.org
New research suggests that, during tubulointerstitial fibrosis, α-smooth muscle actin (SMA)-expressing
mesenchymal cells might derive from the tubular epithelium via epithelial-…
mesenchymal cells might derive from the tubular epithelium via epithelial-…