Background Warfarin is a highly efficacious oral anticoagulant, but its use is limited by a well-founded
fear of bleeding. Drug and food interactions are frequently cited as causes of …

Objective: To systematically review the benefits and risks associated with the use of
benzodiazepines to treat insomnia in adults. Data sources: MEDLINE and the Cochrane Controlled …

Purpose: To evaluate the quality of studies about drugs and food interactions with warfarin
and their clinical relevance. Data Sources: MEDLINE and TOXLINE databases from 1966 to …

Objectives To compare the efficacy and safety of unfractionated heparin (UFH) and low-molecular-weight
heparins (LMWHs) and to examine current controversies in the treatment of …

OBJECTIVE: To analyse the evidence for the efficacy and potential harmful effects of
benzodiazepines compared with other therapies in the treatment of acute alcohol withdrawal. DATA …

Background Computerized decision support systems (CDSS) are believed to have the potential
to improve the quality of health care delivery, although results from high quality studies …

Objectives: To assess patients9 preferred method of consent for the use of information from
electronic medical records for research. Design: Interviews and a structured survey of …

INSOMNIA, OR THE DISSATISFACTION WITH THE QUANTITY, quality or timing of sleep, is
a common complaint. Because the definition of "normal" sleep is not well established, the …

Background: Many Canadians face substantial out-of-pocket charges for prescription drugs.
Prior work suggests that this causes some patients to not take their medications as …

Objective The US Agency for Healthcare Research and Quality funded an evidence report
to address seven questions on multiple aspects of the effectiveness of medication …