In pharmacoeconomics, the comparison of the costs of 2 different drugs used for the same
treatment is of great interest. The problem is especially challenging when the drugs are likely …

Purpose Coumadin‐based oral anticoagulants are associated with a decrease in bone mass
density, but their role in fracture risk is equivocal. Because the use of oral anticoagulants is …

Methods From the Quebec health insurance database we chose a cohort of 4527 women 35
years and older who received social assistance and were new users of estrogen between …

Background: Long-term opioid use is a known risk factor for opioid-related harms. We
aimed to identify risk factors for and predictors of long-term use of prescription opioids in the …

Method: Information on 1994/99 MRCC funding was obtained from the MRCC database for
29 diseases. NIH funding and burden-of-disease counterparts for the year 1996 were …

Background: In Canada, public drug plans may restrict the use of newer topical antiglaucoma
agents. The goals of this retrospective study were to estimate the proportion of patients who…

We correct an equation characterizing the additive allelic effects on fitness determined at many
loci without the assumption of random mating given in Ewens (1989, 1992) and we show …

Using claims databases of a public healthcare program (Quebec) for the years 2010–2013,
we conducted a cohort study of patients with acute ischemic stroke ( AIS ) to describe …

Introduction Published data on the safety of natural medical cannabis (MC) when used in the
real-world clinical practice setting are lacking. This study aimed to describe adverse events …

We show that the Fundamental Theorem of Natural Selection in Ewens' sense is valid in the
case of fertility selection: the additive genetic variance in fertility divided by the mean fertility …