Cannabis use disorder (CUD) is an underappreciated risk of using cannabis that affects ~10%
of the 193 million cannabis users worldwide. The individual and public health burdens …

Drug dependence is a chronic, relapsing disorder in which compulsive drug-seeking and
drug-taking behaviours persist despite serious negative consequences. Addictive substances, …

Tobacco smoking is a major determinant of preventable morbidity and mortality worldwide.
More than a billion people smoke, and without major increases in cessation, at least half will …

Background. Cannabis use is common in North America, especially among young people,
and is associated with a risk of various acute and chronic adverse health outcomes. Cannabis …

A polyclonal antibody was generated using synthetic peptides designed in a specific sequence
of the rat D 3 receptor (D 3 R). Using transfected cells expressing recombinant D 3 R, but …

BACKGROUND: Little is known about the prevalence and comorbidity of Major Depressive
Episode (MDE) during pregnancy in the general population. This study presents nationally …

Background Cannabis use disorder is the most commonly reported illegal substance use
disorder in the general population; although demand for assistance from health services is …

This review examines the development of cannabinoid CB 1 receptor antagonists as a new
class of therapeutic agents for drug addiction. Abused drugs [alcohol, opiates, Δ 9 -…

The function of dopamine D 3 receptors present in the striatum has remained elusive. In the
present study evidence is provided for the existence of dopamine D 1 –D 3 receptor …

Cannabinoids, when co-administered with opioids, may enable reduced opioid doses
without loss of analgesic efficacy (ie, an opioid-sparing effect). The aim of this study was to …