SARS-CoV-2 variants of concern (VOC) are more transmissible and may have the potential
for increased disease severity and decreased vaccine effectiveness. We estimated the …

Objective To estimate the effectiveness of mRNA covid-19 vaccines against symptomatic
infection and severe outcomes (hospital admission or death). Design Test negative design …

… variable selection, with input from Hong Chen and Adrienne Chan on variable selection and
… Branson Chen contributed to data analyses and data preparation for the symptomatic data …

Ultrasound stimulated microbubbles (USMB) are being investigated for their potential to
promote the uptake of anticancer agents into tumor tissue by exploiting their ability to enhance …

The requirement of type I interferon (IFN) for natural killer (NK) cell activation in response to
viral infection is known, but the underlying mechanism remains unclear. Here, we …

Background: Unnecessary antibiotic use in the community in Canada is not well defined.
Our objective was to quantify unnecessary antibiotic prescribing in a Canadian primary care …

Purpose: To explore the potential of ex vivo expanded healthy donor–derived allogeneic
CD4 and CD8 double-negative cells (DNT) as a novel cellular immunotherapy for leukemia …

Significant improvements in the survival of patients with hematological cancers following
hematopoietic stem cell transplantation provide evidence supporting the potency of immune cell…

Considerable effort is being directed toward investigating the use of ultrasound (US) stimulated
microbubbles (MB) to promote the uptake of anticancer agents in tumors. In this study we …

Background Tumor microenvironment (TME) and associated multiple factors are found to
contribute to the failures in cancer therapies, including chemo- and immunotherapy. Here we …