[HTML][HTML] The struggle to end a millennia-long pandemic: novel candidate and repurposed drugs for the treatment of tuberculosis

BD Edwards, SK Field - Drugs, 2022 - Springer
This article provides an encompassing review of the current pipeline of putative and
developed treatments for tuberculosis, including multidrug-resistant strains. The review has …

Assessing the efficacy and safety of hydroxychloroquine as outpatient treatment of COVID-19: a randomized controlled trial

…, G Cerchiaro, C Doram, BD Edwards… - … Open Access Journal, 2021 - cmajopen.ca
Background: Identification of therapies to prevent severe COVID-19 remains a priority. We
sought to determine whether hydroxychloroquine treatment for outpatients with SARS-CoV-2 …

[HTML][HTML] Incidence, treatment, and outcomes of isoniazid mono-resistant Mycobacterium tuberculosis infections in Alberta, Canada from 2007-2017

BD Edwards, J Edwards, R Cooper, D Kunimoto… - PLoS …, 2020 - journals.plos.org
Isoniazid resistant Mycobacterium tuberculosis (Hr-TB) is the most frequently encountered TB
resistance phenotype in North America but limited data exist on the effectiveness of current …

[HTML][HTML] Epidemiology of E. coli in Cystic Fibrosis Airways Demonstrates the Capacity for Persistent Infection but Not Patient-Patient Transmission

C Izydorczyk, B Waddell, BD Edwards… - Frontiers in …, 2020 - frontiersin.org
Escherichia coli is frequently isolated from the respiratory secretions of cystic fibrosis (CF)
patients yet is not considered a classical CF pathogen. Accordingly, little is known about the …

Time to Positive Culture Detection Predicts Mycobacterium avium Pulmonary Disease Severity and Treatment Initiation

BD Edwards, SK Brode, M Mehrabi… - Annals of the American …, 2022 - atsjournals.org
… Correspondence and requests for reprints should be addressed to Brett D. Edwards, MD,
Division of Infectious Diseases, University of Calgary, 3500 26 Avenue Northeast, Calgary, AB, …

Nitrofurantoin-induced liver failure: a fatal yet forgotten complication

…, BD Edwards, D Bates, C Evernden, J Edwards - Canadian Family …, 2021 - cfp.ca
Nitrofurantoin is recommended as first-line therapy for uncomplicated cystitis owing to its
comparable efficacy to cotrimoxazole, minimal resistance, and reduced risk of inducing …

Hepatotoxicity and tuberculosis treatment outcomes in chronic liver disease

BD Edwards, H Mah, NF Sabur… - Journal of the …, 2023 - jammi.utpjournals.press
Background: The treatment of tuberculosis (TB) is known to cause liver injury, however, there
is limited data to guide optimal treatment for patients with chronic liver disease. Methods: …

[HTML][HTML] Prosthetic joint and implant contamination caused by Ralstonia pickettii: a report of three cases

BD Edwards, R Somayaji, B Missaghi, WW Chan… - SICOT-J, 2017 - ncbi.nlm.nih.gov
We describe three cases of orthopaedic contamination caused by Ralstonia pickettii grown
from prosthetic joint and implant material cultures following sonication in the microbiology …

[HTML][HTML] Rifampin-resistant/multidrug-resistant Tuberculosis in Alberta, Canada: Epidemiology and treatment outcomes in a low-incidence setting

BD Edwards, J Edwards, R Cooper, D Kunimoto… - Plos one, 2021 - journals.plos.org
Treatment of rifampin-monoresistant/multidrug-resistant Tuberculosis (RR/MDR-TB) requires
long treatment courses, complicated by frequent adverse events and low success rates. …

Lymphocutaneous spread of Mycobacterium elephantis in an immunocompetent individual: A case report

BD Edwards, R Somayaji, D Fisher… - SAGE Open Medical …, 2021 - journals.sagepub.com
Mycobacterium elephantis was first described when isolated from an elephant that succumbed
to lung abscess. However, despite this namesake, it is not associated with animals and …