Salmonella species cause substantial morbidity, mortality and burden of disease globally.
Infections with Salmonella species cause multiple clinical syndromes. Central to the …

Type III secretion systems (T3SSs) are complex bacterial structures that provide gram-negative
pathogens with a unique virulence mechanism enabling them to inject bacterial effector …

Plasma HDL cholesterol levels are inversely related to risk for atherosclerosis. The ATP-binding
cassette, subfamily A, member 1 (ABCA1) mediates the rate-controlling step in HDL …

Background Elevated proinflammatory cytokines are associated with greater COVID-19 severity.
We aimed to assess safety and efficacy of sarilumab, an interleukin-6 receptor inhibitor, …

Context Clinicians order blood cultures liberally among patients in whom bacteremia is
suspected, though a small proportion of blood cultures yield true-positive results. Ordering blood …

Understanding the significance of bacterial species that colonize and persist in cystic fibrosis
(CF) airways requires a detailed examination of bacterial community structure across a …

Background To date, only monoclonal antibodies have been shown to be effective for
outpatients with COVID-19. Interferon lambda-1 is a type III interferon involved in innate antiviral …

Salmonella species cause a wide range of disease in multiple hosts. Salmonella enterica
serovar Typhimurium causes self-limited intestinal disease in humans and systemic typhoid-…

Background Fecal transplantation (FT) is a promising treatment for recurrent Clostridium
difficile infection (CDI), but its true effectiveness remains unknown. We compared 14 days of …

Anti-programmed cell death protein 1 (PD-1) agents have become the standard of care for
platinum-refractory recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) …