Allocating Scarce Medical Resources for Covid-19 The Covid-19 pandemic has already
stressed health care systems throughout the world, requiring rationing of medical equipment …

Despite abundant evidence that aberrant Rho-family GTPase activation contributes to most
steps of cancer initiation and progression, there is a dearth of inhibitors of their effectors (eg, …

Developing adaptive materials with geometries that change in response to external stimuli
provides fundamental insights into the links between the physical forces involved and the …

The fundamental topology of cellular structures—the location, number and connectivity of
nodes and compartments—can profoundly affect their acoustic 1 , 2 , 3 – 4 , electrical 5 , …

The CDK4/6 inhibitor, palbociclib (PAL), significantly improves progression-free survival in
HR + /HER2 − breast cancer when combined with anti-hormonals. We sought to discover PAL …

Many properties of single‐walled carbon nanotubes (SWCNTs) make them ideal candidates
for sensors, particularly for biological systems. Both their fluorescence in the near‐infrared …

Purpose: To identify and characterize novel, activating mutations in Notch receptors in breast
cancer and to determine response to the gamma secretase inhibitor (GSI) PF-03084014. …

Objectives: We hypothesized that common variants in the collagen genes COL4A1/COL4A2
are associated with sporadic forms of cerebral small vessel disease. Methods: We …

Control of the cell cycle through selective pharmacological inhibition of CDK4/6 has proven
beneficial in the treatment of breast cancer. Extending this level of control to additional cell …

A series of novel compounds have been designed that are potent inhibitors of poly(ADP-ribose)
polymerase-1 (PARP-1), and the activity and physical properties have been …