Background: The effect of multifaceted lifestyle interventions on clinically oriented outcomes
across a spectrum of metabolic risk factors and abnormal glucose is unclear. Purpose: To …

Objective To identify the most commonly presenting conditions in primary care globally, and
to compare common reasons for visits (RFVs) as reported by clinicians and patients, as well …

Background & aims Irritable bowel syndrome (IBS) is one of the most common gastrointestinal
(GI) disorders, affecting about 10% of the general population globally. The aim of this …

Background Skeletal muscle cramps are common and often occur in association with
pregnancy, advanced age, exercise or motor neuron disorders (such as amyotrophic lateral …

Objective To develop a clinical practice guideline for a simplified approach to medical
cannabinoid use in primary care; the focus was on primary care application, with a strong …

Objective To determine the effects of medical cannabinoids on pain, spasticity, and nausea
and vomiting, and to identify adverse events. Data sources MEDLINE, the Cochrane …

Background— Use of cardiovascular disease risk calculators is often recommended by
guidelines, but research on consistency in risk assessment among calculators is limited. Method …

… Korownyk seemed to have misunderstood my motivations. … Korownyk's team's concerns
may be well founded, but that does … Korownyk herself suggests that reanalyzing their data can …

Background Eight out of 10 major antihypertensive trials in older adults attempted to
achieve a target systolic blood pressure (BP) less than 160 mmHg. Collectively these trials …

Objective To develop clinical practice guidelines for a simplified approach to primary
prevention of cardiovascular disease (CVD), concentrating on CVD risk estimation and lipid …