The clinical trial is “the most definitive tool for evaluation of the applicability of clinical research.”
It represents “a key research activity with the potential to improve the quality of health …

The Cardiovascular Health Study (CHS) is a population-based, longitudinal study of coronary
heart disease and stroke in adults aged 65 years and older. The main objective of the …

Background Heart disease is a major cause of illness and death in women. To understand
better the role of estrogen in the treatment and prevention of heart disease, more information …

Atrial fibrillation (AF) is a common arrhythmia in elderly persons and a common cause of
embolic stroke. Most studies of the prevalence and correlates of AF have used selected, hospital…

OBJECTIVE: To propose a tool to assist trialists in making design decisions that are consistent
with their trial's stated purpose. STUDY DESIGN AND SETTING: Randomized trials have …

Background This study aimed to describe the incidence of atrial fibrillation (AF) among older
adults during 3 years of follow-up. Methods and Results In this cohort study, 5201 adults ≥…

The use of antiplatelet therapies continues to increase as a result of accumulation of evidence
of benefits in both primary and secondary treatment strategies for cardiovascular disease. …

Objective. —To review the scientific evidence concerning the safety and efficacy of various
antihypertensive therapies used as first-line agents and evaluated in terms of major disease …

Stroke ranks as the third leading cause of death in the United States. It is now estimated that
there are more than 700000 incident strokes annually and 4.4 million stroke survivors. 1, 2 …

Background The purpose of this study was to assess the effect of the dose of nifedipine, a
dihydropyridine calcium antagonist, on the increased risk of mortality seen in the randomized …