Neural tube defects (NTDs) such as spina bifida and anencephaly are common congenital
malformations in humans (1/1,000 births) that result from failure of the neural tube to close …

The association of nuclear DNA with histones to form chromatin is essential for temporal
and spatial control of eukaryotic genomes. In this study, we examined the physical state of …

We have isolated and sequenced cDNAs for corticosteroid binding globulin (CBG) prepared
from human liver and lung mRNAs. Our results indicate that CBG mRNA is relatively …

Axenfeld–Rieger ocular dysgenesis is associated with mutations of the human PITX2 and
FOXC1 genes, which encode transcription factors of the homeodomain and forkhead types, …

Chromatin undergoes a rapid ATP-dependent, ATM and H2AX-independent decondensation
when DNA damage is introduced by laser microirradiation. Although the detailed …

We have identified alternatively spliced isoforms of murine Pax-3 and Pax-7 which differ by
the presence or absence of a single glutamine residue in a linker region which separates two …

Histone methylation is unique among post-translational histone modifications by virtue of its
stability. It is thought to be a relatively stable and heritable epigenetic mark for gene-specific …

Histone methylation acts as an epigenetic regulator of chromatin activity through the
modification of arginine and lysine residues on histones H3 and H4. In the case of lysine, this …

The mammalian Pax gene family comprises nine members that are characterized by a
conserved DNA-binding motif, the paired domain, which was originally described in the …

Cytotoxic lymphocytes induce target cell apoptosis via two major pathways: Fas/FasL and
granule exocytosis. The latter pathway has largely been defined by the roles of the pore-…