The number of published systematic reviews of studies of healthcare interventions has
increased rapidly and these are used extensively for clinical and policy decisions. Systematic …

OBJECTIVE: Our purpose was to measure the agreement, reliability, construct validity, and
feasibility of a measurement tool to assess systematic reviews (AMSTAR). STUDY DESIGN …

Background Concerns regarding the safety of transfused blood have led to the development
of a range of interventions to minimise blood loss during major surgery. Anti‐fibrinolytic …

Background: Most proton pump inhibitors inhibit the bioactivation of clopidogrel to its active
metabolite. The clinical significance of this drug interaction is unknown. Methods: We …

Purpose This study compared denosumab, a fully human monoclonal anti-receptor activator
of nuclear factor kappa-B ligand antibody, with zoledronic acid (ZA) for delaying or …

Background Chronic immune thrombocytopenic purpura (ITP) is characterised by accelerated
platelet destruction and decreased platelet production. Short-term administration of the …

Background Concerns regarding the safety of transfused blood have prompted reconsideration
of the use of allogeneic (from an unrelated donor) red blood cell (RBC) transfusion, and …

Although research has found that urban youth are exposed to excessive levels of community
violence, few studies have focused on the factors that alter the risk of exposure to violence …

PURPOSE Kaposi's sarcoma (KS), the most common neoplasm in patients with AIDS, is a
significant clinical problem for which current therapies are frequently unsatisfactory. We …

BACKGROUND: Patients with bone metastases from advanced cancer often experience
skeletal-related events (SRE), which cause substantial pain and morbidity. Denosumab, a fully …