Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA

…, M Wagner, C Brandmayr, SK Laube, D Eisen… - Nature chemical …, 2014 - nature.com
Ten eleven translocation (Tet) enzymes oxidize the epigenetically important DNA base 5-methylcytosine
(mC) stepwise to 5-hydroxymethylcytosine (hmC), 5-formylcytosine and 5-…

Identification and quantification of a new family of peptide endocannabinoids (Pepcans) showing negative allosteric modulation at CB1 receptors

M Bauer, A Chicca, M Tamborrini, D Eisen… - Journal of biological …, 2012 - ASBMB
The α-hemoglobin-derived dodecapeptide RVD-hemopressin (RVDPVNFKLLSH) has been
proposed to be an endogenous agonist for the cannabinoid receptor type 1 (CB 1 ). To …

[PDF][PDF] TET3 is recruited by REST for context-specific hydroxymethylation and induction of gene expression

A Perera, D Eisen, M Wagner, SK Laube, AF Künzel… - Cell reports, 2015 - cell.com
Ten-eleven translocation hydroxylases (TET1-3) oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine
(5hmC). In neurons, increased 5hmC levels within gene bodies correlate …

Structural insights into the recognition of cisplatin and AAF-dG lesion by Rad14 (XPA)

…, N Simon, R Strasser, D Eisen… - Proceedings of the …, 2015 - National Acad Sciences
Nucleotide excision repair (NER) is responsible for the removal of a large variety of
structurally diverse DNA lesions. Mutations of the involved proteins cause the xeroderma …

Socioeconomic and immigration status and COVID-19 testing in Toronto, Ontario: retrospective cross-sectional study

…, S Hum, P Gill, M Greiver, A Kirubarajan, D Eisen… - BMC public health, 2022 - Springer
David Eisen … Michelle Greiver & David EisenDavid Eisen

Orchestrating the biosynthesis of an unnatural pyrrolysine amino acid for its direct incorporation into proteins inside living cells

…, B Viverge, J Bretzler, D Eisen… - … A European Journal, 2015 - Wiley Online Library
We here report the construction of an E. coli expression system able to manufacture an
unnatural amino acid by artificial biosynthesis. This can be orchestrated with incorporation into …

Acute esophageal necrosis associated with gastric volvulus

M Kram, L Gorenstein, D Eisen… - Gastrointestinal …, 2000 - giejournal.org
Discussion AEN is a rare event. Often described as the black esophagus, AEN must be
distinguished from other entities that can give the appearance endoscopically of a black …

Health system use among patients with mental health conditions in a community based sample in Toronto, Canada: A retrospective cohort study

…, B Aliarzadeh, S Bernard, R Moineddin, D Eisen… - Plos one, 2022 - journals.plos.org
Objective To identify hospital and primary care health service use among people with
mental health conditions or addictions in an integrated primary-secondary care database in …

Orbitocranial penetration by a fern: case report

RJ Kahler, FH Tomlinson, DP Eisen, JP Masel - Neurosurgery, 1998 - journals.lww.com
OBJECTIVE AND IMPORTANCE: Cranial and orbitocranial penetration by organic foreign
material is not infrequent. It is important to identify whether penetration has occurred and to …

Choosing Wisely: An idea worth sustaining

…, M Asalya, L Jussaume, D Eisen… - Health Services …, 2022 - Wiley Online Library
Objectives To evaluate the sustainability potential of Choosing Wisely (CW) to address
unnecessary medical care at Ontario community hospitals. Data Sources/Study Setting Ontario …