Background: Most proton pump inhibitors inhibit the bioactivation of clopidogrel to its active
metabolite. The clinical significance of this drug interaction is unknown. Methods: We …

Background A number of approaches have been used to grade levels of evidence and the
strength of recommendations. The use of many different approaches detracts from one of the …

Purpose. To evaluate the safety and efficacy of intravenous (IV) sodium ferric gluconate
complex (FG), oral ferrous sulfate, or no iron to increase hemoglobin (Hb) in anemic cancer …

Background: Characterizing high-cost users of health care resources is essential for the
development of appropriate interventions to improve the management of these patients. We …

The number of published systematic reviews of studies of healthcare interventions has
increased rapidly and these are used extensively for clinical and policy decisions. Systematic …

Non-randomised studies of the effects of interventions are critical to many areas of healthcare
evaluation, but their results may be biased. It is therefore important to understand and …

OBJECTIVE: Our purpose was to measure the agreement, reliability, construct validity, and
feasibility of a measurement tool to assess systematic reviews (AMSTAR). STUDY DESIGN …

Background Concerns regarding the safety of transfused blood have led to the development
of a range of interventions to minimise blood loss during major surgery. Anti‐fibrinolytic …

… Ray Moynihan, Iona Heath, and David Henry give examples of “disease mongering” and
suggest how to prevent … We thank David Newby for his help in conducting literature searches. …

Background Chronic immune thrombocytopenic purpura (ITP) is characterised by accelerated
platelet destruction and decreased platelet production. Short-term administration of the …