The recognition that nutrients have the ability to interact and modulate molecular mechanisms
underlying an organism's physiological functions has prompted a revolution in the field of …

Circulating fatty acids (FA) are associated with a multitude of chronic diseases. However, a
major gap in establishing such relationships is the lack of accepted fatty acid reference …

The use of modern molecular biology tools in deciphering the perturbed biochemistry and
physiology underlying the obese state has proven invaluable. Identifying the hypothalamic …

Background The biomedical community is developing new methods of data analysis to more
efficiently process the massive data sets produced by microarray experiments. Systematic …

Food preferences and dietary habits are heavily influenced by taste perception. There is
growing interest in characterizing taste preferences based on genetic variation. Genetic …

Recent evidence indicates that genetic variation in fatty acid desaturases 1 and 2 (FADS1
and FADS2) is associated with changes in plasma fatty acid profiles; however, the association …

Perturbations in lipid metabolism characterize many of the chronic diseases currently plaguing
our society, such as obesity, diabetes, and cardiovascular disease. Thus interventions …

Obesity is a risk factor for the development of type 2 diabetes and cardiovascular disease.
However, it is now recognized that a subset of individuals have reduced cardiometabolic risk …

A subgroup of obese individuals, referred to as metabolically healthy obese (MHO), have
preserved insulin sensitivity and a normal lipid profile despite being obese. The molecular …

Background It has long been believed that DHA supplementation increases plasma EPA via
the retroconversion pathway in mammals. However, in rodents this increase in EPA is likely …