Background Rimegepant, a small molecule calcitonin gene-related peptide receptor antagonist,
has shown efficacy in the acute treatment of migraine using a standard tablet formulation…

Background Calcitonin gene–related peptide receptor has been implicated in the pathogenesis
of migraine. Rimegepant is an orally administered, small-molecule, calcitonin gene–…

Background BMS-927711 is a potent, selective, competitive human calcitonin gene-related
peptide (CGRP) receptor antagonist that has shown in vivo efficacy without vasoconstrictor …

Hedgehog (Hh) proteins are responsible for critical signalling events during development 1
but their evolutionary roles remain to be determined. Here we show that hh gene expression …

The construction of organisms from units that develop under semi–autonomous genetic
control (modules) has been proposed to be an important component of their ability to undergo …

The analysis of gas-droplet flows is complicated by the need to account for the mass, momentum,
and energy coupling between phases. The concept of regarding the droplet phase as …

Background Rimegepant is a calcitonin gene-related peptide receptor antagonist that has
shown efficacy and safety in the acute treatment of migraine. We aimed to compare the …

4-Thiazolidinones were synthesized and evaluated for their ability to inhibit the bacterial
enzyme MurB. Selected 4-thiazolidinones displayed activity against the enzyme in vitro. This …

In the past many mechanisms of action have been proposed to explain the surfactant‐induced
uptake of agrochemicals applied to foliage. These are reviewed briefly and discussed in …

The vertebrate Dlx gene family consists of homeobox-containing transcription factors distributed
in pairs on the same chromosomes as the Hox genes. To investigate the evolutionary …