Background Physical frailty and sarcopenia show extensive clinical similarities. Whether
biomarkers exist that are shared by the two conditions is presently unclear. Methods We …

Anorexia of aging, defined as a loss of appetite and/or reduced food intake, affects a significant
number of elderly people and is far more prevalent among frail individuals. Anorexia …

Purpose Adverse drug reactions (ADRs) represent a common and potentially preventable
cause of unplanned hospitalization, increasing morbidity, mortality, and healthcare costs. We …

Background We evaluated whether frailty and multimorbidity predict in-hospital mortality in
patients with COVID-19 beyond chronological age. Method A total of 165 patients admitted …

Introduction Cardiometabolic diseases (CMDs) have been individually associated with adverse
cognitive outcomes, but their combined effect has not been investigated. Methods A total …

Aims Cardiometabolic diseases (CMDs), including diabetes, heart disease, and stroke, are
established risk factors for dementia, but their combined impact has been investigated only …

People with Down Syndrome (DS) have a high prevalence of physical and psychiatric
comorbidities and experience early-onset dementia. With the outbreak of CoVID-19 pandemic, …

This study analyzed data of bone mineral density (BMD) from a large cohort of adults with
Down syndrome (DS). BMD was found to decrease with age more rapidly in these subjects …

Objectives To test the association between polypharmacy and 1-year change in physical
and cognitive function among nursing home (NH) residents. Design Longitudinal multicenter …

Background Multimorbidity, the coexistence of multiple chronic diseases in an individual, is
highly prevalent and challenging for healthcare systems. However, its risk factors remain …