The rapid growth of human genetics creates countless opportunities for studies of disease
association. Given the number of potentially identifiable genetic markers and the multitude of …

ContextThere is substantial debate about whether the results of nonrandomized studies are
consistent with the results of randomized controlled trials on the same topic.ObjectivesTo …

Background Advances in human genetics could help us to assess prognosis on an individual
basis and to optimise the management of complex diseases. However, different studies on …

It has long been an axiom in clinical pediatrics that “children are not just little adults.” It has
also been recognized that there are many changes from birth through childhood and the …

Purpose To evaluate the predictors of and time taken for the translation of highly promising
basic research into clinical experimentation and use. Methods We identified 101 articles, …

Objective To provide estimates of the relative rate of COVID-19 death in people <65 years
old versus older individuals in the general population, the absolute risk of COVID-19 death at …

Recommendations for the Future Our analysis documents objectively show the long length
of time that passes between discovery and translation. As scientists, we should convey to our …

Objective To determine how often health surveys and quality of life evaluations reach different
conclusions from those of primary efficacy outcomes and whether discordant results make …

The largest burden of COVID-19 is carried by the elderly, and persons living in nursing
homes are particularly vulnerable. However, 94% of the global population is younger than 70 …

Background. There has been a long-standing debate regarding whether aminoglycosides
should be administered on a multiple daily dosing (MDD) or once-daily dosing (ODD) …