Effect of screening with primary cervical HPV testing vs cytology testing on high-grade cervical intraepithelial neoplasia at 48 months: the HPV FOCAL randomized …

GS Ogilvie, D van Niekerk, M Krajden, LW Smith… - Jama, 2018 - jamanetwork.com
Importance There is limited information about the relative effectiveness of cervical cancer
screening with primary human papillomavirus (HPV) testing alone compared with cytology in …

The path to eliminating cervical cancer in Canada: past, present and future directions

H Caird, J Simkin, L Smith, D Van Niekerk, G Ogilvie - Current Oncology, 2022 - mdpi.com
Cervical cancer remains a common cancer affecting women in Canada. While cervical cancer
incidence and mortality in Canada have declined for several decades due to the success …

Screening for the prevention and early detection of cervical cancer: protocol for systematic reviews to inform Canadian recommendations

…, BD Thombs, J Little, C Popadiuk, D Van Niekerk… - Systematic …, 2021 - Springer
Purpose To inform recommendations by the Canadian Task Force on Preventive Health Care
on screening in primary care for the prevention and early detection of cervical cancer by …

HPV for cervical cancer screening (HPV FOCAL): Complete Round 1 results of a randomized trial comparing HPV‐based primary screening to liquid‐based cytology …

GS Ogilvie, M Krajden, D van Niekerk… - … journal of cancer, 2017 - Wiley Online Library
Complete Round 1 data (baseline and 12‐month follow‐up) for HPV FOCAL, a randomized
trial establishing the efficacy of HPV DNA testing with cytology triage as a primary screen for …

Primary hrHPV DNA testing in cervical cancer screening: how to manage screen-positive women? A POBASCAM trial substudy

…, D van Niekerk, DC Rijkaart, FJ van Kemenade… - … , biomarkers & prevention, 2014 - AACR
Background: High-risk human papillomavirus (hrHPV) testing has higher sensitivity but lower
specificity than cytology for cervical (pre)-cancerous lesions. Therefore, triage of hrHPV-…

A randomized controlled trial of H uman P apilloma v irus (HPV) testing fo rc ervic al cancer screening: trial design and preliminary results (HPV FOCAL Trial)

GS Ogilvie, DJ van Niekerk, M Krajden, RE Martin… - BMC cancer, 2010 - Springer
Background In the HPV FOCAL trial, we will establish the efficacy of hr-HPV DNA testing as
a stand-alone screening test followed by liquid based cytology (LBC) triage of hr-HPV-…

Community-integrated self-collected HPV-based cervix screening in a low-resource rural setting: a pragmatic, cluster-randomized trial

…, PN Simelela, J Singer, LW Smith, D Van Niekerk… - Nature Medicine, 2023 - nature.com
Effective approaches to improve coverage of self-collected human papillomavirus (HPV)-based
cervix screening (SCS) as well as attendance at treatment for HPV-positive participants …

Evaluation of a validated methylation triage signature for human papillomavirus positive women in the HPV FOCAL cervical cancer screening trial

…, JH Law, LW Smith, DJ van Niekerk… - … Journal of Cancer, 2019 - Wiley Online Library
Human papillomavirus (HPV)‐based cervical cancer screening requires triage of HPV
positive women to identify those at risk of cervical intraepithelial neoplasia grade 2 (CIN2) or …

Automatic labeling of molecular biomarkers of immunohistochemistry images using fully convolutional networks

F Sheikhzadeh, RK Ward, D van Niekerk, M Guillaud - PloS one, 2018 - journals.plos.org
This paper addresses the problem of quantifying biomarkers in multi-stained tissues based
on the color and spatial information of microscopy images of the tissue. A deep learning-…

Women's intentions to receive cervical cancer screening with primary human papillomavirus testing

GS Ogilvie, LW Smith, DJ van Niekerk… - … journal of cancer, 2013 - Wiley Online Library
We explored the potential impact of human papillomavirus (HPV) testing on women's intentions
to be screened for cervical cancer in a cohort of Canadian women. Participants aged 25–…