BACKGROUND Cost-effectiveness analysis involves the comparison of the incremental cost-effectiveness
ratio of a new technology, which is more costly than existing alternatives, with …

Background No consensus exists on whether preoperative blood transfusions are beneficial
in patients with sickle-cell disease. We assessed whether perioperative complication rates …

Background The current recommendation of using transrectal ultrasound-guided biopsy (TRUSB)
to diagnose prostate cancer misses clinically significant (CS) cancers. More sensitive …

Background Depression is a significant cause of morbidity. Many patients have communicated
an interest in non-pharmacological therapies to their general practitioners. Systematic …

Literature reviews underpin the majority of research projects in the health sciences, and yet
relatively little analysis has been published as to the most appropriate method to identify …

Background: The general issue of balancing the value of evidence about the performance of
a technology and the value of access to a technology can be seen as central to a number of …

Background: Tumour necrosis factor (TNF)-α inhibitors (anti-TNFs) are typically used when
the inflammatory rheumatologic diseases ankylosing spondylitis (AS) and non-radiographic …

BACKGROUND Men with suspected prostate cancer usually undergo transrectal ultrasound
(TRUS)-guided prostate biopsy. TRUS-guided biopsy can cause side effects and has …

Background With impending marijuana legislation in Canada, a broad understanding of the
harms associated with marijuana use is needed to inform the clinical community and public, …

Background Screening is an important part of preventive medicine. Ideally, screening tools
identify patients early enough to provide treatment and avoid or reduce symptoms and other …