Cerebral small vessel disease (SVD) is a common accompaniment of ageing. Features
seen on neuroimaging include recent small subcortical infarcts, lacunes, white matter …

Background Among patients with a proximal vessel occlusion in the anterior circulation, 60
to 80% of patients die within 90 days after stroke onset or do not regain functional …

In many human infections, hosts and pathogens coexist for years or decades. Important
examples include HIV, herpes viruses, tuberculosis, leprosy, and malaria. With the exception of …

Importance Randomized clinical trials suggest the benefit of intravenous tissue-type plasminogen
activator (tPA) in acute ischemic stroke is time dependent. However, modest sample …

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans and is
characterized by chaotic electrical activity of the atria 1 . It affects one in ten individuals over the …

Background— The benefits of intravenous tissue-type plasminogen activator (tPA) in acute
ischemic stroke are time dependent, and guidelines recommend an arrival to treatment …

Background and Purpose— Stroke mortality has been declining since the early 20th century.
The reasons for this are not completely understood, although the decline is welcome. As a …

This publication, commissioned by the ACC/AHA, is the product of a novel collaboration
between the ACC and AHA, the US Food and Drug Administration (FDA), and the Standardized …

Importance The benefits of intravenous tissue plasminogen activator (tPA) in patients with
acute ischemic stroke (AIS) are time dependent and guidelines recommend a door-to-needle (…

Background— Adherence to evidence-based guidelines for treatment of stroke or transient
ischemic attack is suboptimal. We sought to establish whether participation in Get With the …