The mechanisms by which mutations in FUS and other RNA binding proteins cause ALS and
FTD remain controversial. We propose a model in which low-complexity (LC) domains of …

We report observations of an intrinsic fluorescence in the visible range, which develops during
the aggregation of a range of polypeptides, including the disease-related human peptides …

Background Clinical drug trials in patients with heart failure and preserved ejection fraction
have failed to demonstrate improvements in mortality. Methods We systematically searched …

Insight into how amyloid β (Aβ) aggregation occurs in vivo is vital for understanding the
molecular pathways that underlie Alzheimer's disease and requires new techniques that provide …

Many important biological functions, and dysfunctions, involve the self-assembly of molecules.
Two well-characterised examples are the clustering of signalling proteins in cellular …

It is unclear whether mutations in fused in sarcoma (FUS) cause familial amyotrophic lateral
sclerosis via a loss-of-function effect due to titrating FUS from the nucleus or a gain-of-…

The phenomenon of protein misfolding and aggregation is one of the most important topics
in current biomedical research.[1] The failure of proteins to fold correctly, or to remain …

Stem cells have demonstrated encouraging potential as reparative therapy for patients
suffering from post-stroke disability. Reperfusion interventions in the acute phase of stroke have …

Short-term outcomes in eyes with posterior capsule rupture d... : Journal of Cataract &
Refractive Surgery Short-term outcomes in eyes with posterior capsule rupture during cataract …

In order to address the increasing global impacts of white‐collar and corporate crime,
theoretical development that can advance our understanding of their causes and covariates is …