Context National public insurance for drugs is often based on evidence of comparative
effectiveness and cost-effectiveness. This study describes how that evidence has been used …

Background & Aims Inflammatory bowel diseases (IBDs) exist worldwide, with high prevalence
in North America. IBD is complex and costly, and its increasing prevalence places a …

Objective The objective of this study was to establish the effectiveness of interventions to
reduce frequent emergency department (ED) use among a general adult high ED-use …

Background The Alberta Kidney Disease Network is a collaborative nephrology research
organization based on a central repository of laboratory and administrative data from the …

Background: Statins were initially used to improve cardiovascular outcomes in people with
established coronary artery disease, but recently their use has become more common in …

COVID-19 has driven the need for timely evidence to inform decision-making. Rapid evidence
products can be particularly helpful for decision-makers (eg, citizens, patients, health care …

Background Treatment of hypertension in patients with diabetes mellitus (DM) has been shown
to improve cardiovascular outcomes; however, the value of intensive blood pressure (BP…

BACKGROUND: Radiofrequency ablation (RFA), a procedure using heat to interrupt pain
signals in spinal nerves, is an emerging treatment option for chronic low back pain. Its clinical …

Background The role of patient involvement in health research has evolved over the past
decade. Despite efforts to engage patients as partners, the role is not well understood. We …

Background Although obstructive sleep apnea (OSA) is more common in patients with
kidney disease, whether nocturnal hypoxia affects kidney function is unknown. Methods We …