… *MP Blaustein and FHH Leenen contributed equally to this … *MP Blaustein and FHH Leenen
contributed equally to this … ; additional details and references are provided in Leenen (148). …

Na + -transport regulating mechanisms classically considered to reflect renal control of
sodium homeostasis and BP, ie aldosterone–mineralocorticoid receptors (MR)—epithelial …

The classical neurotransmitters, glutamate and GABA, mediate fast (milliseconds) synaptic
transmission and modulate its effectiveness through slow (seconds to minutes) signaling …

ContextFew cardiovascular outcome data are available for blacks with hypertension treated
with angiotensin-converting enzyme (ACE) inhibitors or calcium channel blockers (CCBs).…

Background Analyses of medication databases indicate marked increases in prescribing of
antihypertensive drugs in Canada over the past decade. This study was done to examine the …

Background Optimal first-step antihypertensive drug therapy in type 2 diabetes mellitus (DM)
or impaired fasting glucose levels (IFG) is uncertain. We wished to determine whether …

Background: Available information on the prevalence and management of hypertension in
the Canadian population dates back to 1986–1992 and probably does not reflect the current …

The Antihypertensive and Lipid-Lowering treatment to prevent Heart Attack Trial (ALLHAT)
provides a unique opportunity to compare the long-term relative safety and efficacy of …

Estrogens have been implicated in both worsening and protecting from cardiovascular disease.
The effects of 17β-estradiol (E2) on the cardiovascular system may be mediated, at least …

Epithelial sodium channels (ENaC) are important for regulating sodium transport across
epithelia. Functional studies indicate that neural mechanisms acting through mineralocorticoid …