CYP24A1 is the cytochrome P450 component of the 25-hydroxyvitamin D 3 -24-hydroxylase
enzyme that catalyzes the conversion of 25-hydroxyvitamin D 3 (25-OH-D 3 ) and 1,25-…

Jones, Glenville, Stephen A. Strugnell, and Hector F. DeLuca. Current Understanding of the
Molecular Actions of Vitamin D. Physiol. Rev. 78: 1193–1231, 1998.—The important …

Bioactivation of vitamin D consists of two sequential hydroxylation steps to produce 1α,25-dihydroxyvitamin
D 3 . It is clear that the second or 1α-hydroxylation step is carried out by a …

This article summarizes the new 2011 report on dietary requirements for calcium and vitamin
D from the Institute of Medicine (IOM). An IOM Committee charged with determining the …

Although researchers first identified the fat-soluble vitamin cholecalciferol almost a century
ago and studies have now largely elucidated the transcriptional mechanism of action of its …

Six cytochrome P450 (CYP) isoforms have been shown to hydroxylate vitamin D. Four of
these, CYP27A1, CYP2R1, CYP3A4 and CYP2J3, are candidates for the enzyme vitamin D 25-…

Background Vitamin D supplementation for the prevention of rickets is one of the oldest and
most effective prophylactic measures in medicine, having virtually eradicated rickets in North …

In early 2011, a committee convened by the Institute of Medicine issued a report on the Dietary
Reference Intakes for calcium and vitamin D. The Endocrine Society Task Force in July …

The vitamin D signal transduction system involves a series of cytochrome P450-containing
sterol hydroxylases to generate and degrade the active hormone, 1α,25-dihydroxyvitamin D 3 …

Retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA play important
roles in regulating gene expression, through interactions with nuclear receptors, during …