Objective Concerns persist about a possible association between tumor necrosis factor α (TNFα)
antagonist treatment and development of cancers in patients with rheumatoid arthritis (…

Background Clinical trials and meta-analyses have found that rosiglitazone maleate, a
thiazolidinedione that is prescribed for type 2 diabetes mellitus, increases the risk of fractures in …

Background The use of diuretics, statins, and inhaled long-acting β2-agonists (LABAs) is
linked to muscle cramps but largely by anecdotal evidence. This study sought population-level …

Background: Isotretinoin, a teratogen, is widely used to treat cystic acne. Although the risks of
pregnancy during isotretinoin therapy are well recognized, there are doubts about the level …

Background The association between hydrochlorothiazide (HCTZ) and skin cancer remains
controversial. Objective To determine whether HCTZ is associated with an increased risk of …

Introduction Several new oral drug classes for type 2 diabetes (T2DM) have been introduced
in the last 20 years accompanied by developments in clinical evidence and guidelines. The …

The initial and relative evaluation of computer methodologies developed for assisting diagnosis
in mammography is usually done by comparing the computer output to ground truth data …

Background: Direct oral anticoagulants (DOACs) have widely replaced warfarin for stroke
prevention in nonvalvular atrial fibrillation. Our objective was to compare the safety and …

Introduction: Knowledge translation (KT) initiatives have the potential to improve prescribing
quality and produce savings that exceed the cost of the KT program itself, including the cost …

Objective To evaluate the impact of personalized prescribing portraits on antibiotic prescribing
for treating uncomplicated acute cystitis (UAC) by Family Physicians (FPs). Design Cluster …