Background Tens of millions of children are exposed to Mycobacterium tuberculosis
globally every year; however, there are no contemporary estimates of the risk of developing …

Background BCG vaccines are given to more than 100 million children every year, but there
is considerable debate regarding the effectiveness of BCG vaccination in preventing …

Background Active case finding is a top priority for the global control of tuberculosis, but
robust evidence for its effectiveness in high-prevalence settings is lacking. We sought to …

Background Accurate estimates of long-term mortality following tuberculosis treatment are
scarce. This systematic review and meta-analysis aimed to estimate the post-treatment …

Investigation of contacts of patients with tuberculosis (TB) is a priority for TB control in high-income
countries, and is increasingly being considered in resource-limited settings. This …

Background The World Health Organization has set ambitious targets for the global elimination
of tuberculosis. However, these targets will not be achieved at the current rate of progress…

The global drive to vaccinate against severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)
began in December 2020 with countries in Europe, Middle East, and North …

Background Treatment outcomes for multidrug-resistant tuberculosis remain poor. We aimed
to estimate the association of treatment success and death with the use of individual drugs, …

Current World Health Organisation targets calling for an end to the global tuberculosis (TB)
epidemic by 2035 require a dramatic improvement in current case-detection strategies. A …

Prevention of multidrug-resistant and extensively drug-resistant tuberculosis (MDR/XDR-TB)
is a top priority for global TB control, given the need to limit epidemic spread and …