Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density
lipoprotein cholesterol and triglycerides are among the most important risk factors for …

Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …

Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…

Background Stroke is a leading cause of death and disability, especially in low-income and
middle-income countries. We sought to quantify the importance of potentially modifiable risk …

Chronic kidney disease (CKD) has a heritable component and is an important global public
health problem because of its high prevalence and morbidity 1 . We conducted genome-…

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease.
We report the largest genetic association study of blood pressure traits (systolic, diastolic …

Background Embolic strokes of undetermined source represent 20% of ischemic strokes and
are associated with a high rate of recurrence. Anticoagulant treatment with rivaroxaban, an …

Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies
have identified common CKD susceptibility variants. The CKDGen consortium performed …

Background It has been suggested that clopidogrel may be less effective in reducing the
rate of cardiovascular events among persons who are carriers of loss-of-function CYP2C19 …

Background Various genome-wide association studies (GWAS) have been done in ischaemic
stroke, identifying a few loci associated with the disease, but sample sizes have been …