User profiles for Harry L.A. Janssen

Harry LA Janssen

Professor of Medicine, Erasmus MC, Rotterdam, Netherlands
Verified email at erasmusmc.nl
Cited by 68764

EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection

…, K Agarwal, T Berg, M Buti, HLA Janssen… - Journal of …, 2017 - Elsevier
Hepatitis B virus (HBV) infection remains a global public health problem with changing
epidemiology due to several factors including vaccination policies and migration. This Clinical …

[HTML][HTML] Treatment of HCV infection by targeting microRNA

HLA Janssen, HW Reesink, EJ Lawitz… - … England Journal of …, 2013 - Mass Medical Soc
Background The stability and propagation of hepatitis C virus (HCV) is dependent on a
functional interaction between the HCV genome and liver-expressed microRNA-122 (miR-122). …

Association between sustained virological response and all-cause mortality among patients with chronic hepatitis C and advanced hepatic fibrosis

…, WP Hofmann, RJ De Knegt, BE Hansen, HLA Janssen - Jama, 2012 - jamanetwork.com
… lecture activities or patents from Merck, Janssen, Roche, Gilead, and Medtronic, and research
grants from Merck and Roche. Dr Janssen reported receiving financial compensation for …

Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial

HLA Janssen, M van Zonneveld, H Senturk, S Zeuzem… - The Lancet, 2005 - thelancet.com
Background Treatment of HBeAg-positive patients with chronic hepatitis B is not effective in
most. A combination of immunomodulatory pegylated interferon alfa-2b and antiviral …

Sustained virologic response and clinical outcomes in patients with chronic hepatitis C and advanced fibrosis

…, BE Hansen, SW Schalm, HLA Janssen - Annals of internal …, 2007 - acpjournals.org
Background: Clinical outcomes of chronic hepatitis C infection in patients with advanced
fibrosis include liver failure, hepatocellular carcinoma, and death. Objective: To investigate …

[PDF][PDF] Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection

…, EJ Kuipers, JG Kusters, HLA Janssen - …, 2005 - Wiley Online Library
Chronic hepatitis B virus (HBV) infection is characterized by a weak immune response to
HBV. Regulatory T cells (T reg ) can suppress the function of effector T cells and may thus be …

PAGE-B predicts the risk of developing hepatocellular carcinoma in Caucasians with chronic hepatitis B on 5-year antiviral therapy

…, R Idilman, M Colombo, R Esteban, HLA Janssen… - Journal of …, 2016 - Elsevier
Background & Aims Risk scores for hepatocellular carcinoma (HCC) developed in Asians
offer poor-moderate predictability in Caucasian patients with chronic hepatitis B (CHB). This …

[PDF][PDF] Elevated levels of von Willebrand Factor in cirrhosis support platelet adhesion despite reduced functional capacity

T Lisman, TN Bongers, J Adelmeijer, HLA Janssen… - …, 2006 - Wiley Online Library
Cirrhosis of the liver is frequently accompanied by complex alterations in the hemostatic
system, resulting in a bleeding tendency. Although many hemostatic changes in liver disease …

[HTML][HTML] Acute portal vein thrombosis unrelated to cirrhosis: a prospective multicenter follow‐up study

…, M Primignani, JC Garcia‐Pagan, HLA Janssen… - …, 2010 - Wiley Online Library
Current recommendations for early anticoagulation in acute portal vein thrombosis unrelated
to cirrhosis or malignancy are based on limited evidence. The aim of this study was to …

Hepatitis B virus infection

…, DS Chen, GM Dusheiko, HLA Janssen… - Nature reviews Disease …, 2018 - nature.com
Hepatitis B virus (HBV) is a hepatotropic virus that can establish a persistent and chronic
infection in humans through immune anergy. Currently, 3.5% of the global population is …